发明申请
- 专利标题： ISOINDOLINE PDE10 INHIBITORS
- 专利标题（中）： ISOINDOLINE PDE10抑制剂
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申请号： US13825616申请日： 2011-10-24
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公开(公告)号： US20130203756A1公开(公告)日： 2013-08-08
- 发明人: Jamie L. Bunda , Christopher D. Cox , Vadim Y. Dudkin , Hannah D. Fiji , Michael J. Kelly , Mark E. Layton , Joseph E. Pero , William D. Shipe , Justin T. Sheen
- 申请人： Jamie L. Bunda , Christopher D. Cox , Vadim Y. Dudkin , Hannah D. Fiji , Michael J. Kelly , Mark E. Layton , Joseph E. Pero , William D. Shipe , Justin T. Sheen
- 国际申请： PCT/US11/57420 WO 20111024
- 主分类号： C07D403/06
- IPC分类号： C07D403/06 ; C07D519/00 ; C07D417/14 ; C07D413/14 ; C07D471/04
摘要：
The present invention is directed to isoindolinone compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
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