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公开(公告)号:US20230227441A1
公开(公告)日:2023-07-20
申请号:US18009306
申请日:2021-06-14
申请人: Ashok ARASAPPAN , Ian M. BELL , Christopher James BUNGARD , Christopher S. BURGEY , Jason M. COX , Deodial Guy GUIADEEN , Michael J. KELLY , Mark E. LAYTON , Hong LIU , Jian LIU , James T. OLSEN , James J. PERKINS , Jeffrey W. SCHUBERT , Akshay A. SHAH , Michael D. VANHEYST , Zhe WU , Shawn J. STACHEL , MERCK SHARP & DOHME CORP.
发明人: Ashok Arasappan , Ian M. Bell , Christopher James Bungard , Christopher S. Burgey , Jason Michael Cox , Deodial Guy Guiadeen, III , Michael J. Kelly, III , Mark E. Layton , Hong Liu , Jian Liu , James T. Olsen , James J. Perkins , Jeffrey W. Schubert , Akshay A. Shah , Shawn J. Stachel , Michael David VanHeyst , Zhe Wu
IPC分类号: C07D413/12 , C07D263/24 , C07D417/12
CPC分类号: C07D413/12 , C07D263/24 , C07D417/12
摘要: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.
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公开(公告)号:US09264230B2
公开(公告)日:2016-02-16
申请号:US13047344
申请日:2011-03-14
申请人: Todd W. Arnold , Elizabeth A. Dames , Thomas J. Dewkett , Carsten D. Frehr , Michael J. Kelly , Kenneth B. Kerr , Richard V. Kisley , Eric D. Rossman , Eric B. Smith
发明人: Todd W. Arnold , Elizabeth A. Dames , Thomas J. Dewkett , Carsten D. Frehr , Michael J. Kelly , Kenneth B. Kerr , Richard V. Kisley , Eric D. Rossman , Eric B. Smith
CPC分类号: H04L9/0897
摘要: A system for implementing computer security is provided. The system includes a computer processor and an application configured to execute on the computer processor, the application implementing a method that includes creating a token and populating a payload section of the token with key material and selecting a wrapping method that specifies how the key material is securely bound to key control information. A structure of the key control information in the token is independent of the wrapping method. Implementing computer security also includes wrapping the key material and binding key control information to the key material in the token. The key control information includes information relating to usage and management of the key material.
摘要翻译: 提供了一种实现计算机安全的系统。 该系统包括计算机处理器和被配置为在计算机处理器上执行的应用程序,该应用程序实现一种方法,该方法包括使用密钥材料创建令牌和填充令牌的有效载荷部分,并且选择包装方法,该方法指定密钥材料 安全地绑定到关键控制信息。 令牌中的关键控制信息的结构与包装方法无关。 实施计算机安全还包括将密钥材料和密钥控制信息绑定到令牌中的密钥材料。 关键控制信息包括与密钥材料的使用和管理有关的信息。
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公开(公告)号:US20130203756A1
公开(公告)日:2013-08-08
申请号:US13825616
申请日:2011-10-24
申请人: Jamie L. Bunda , Christopher D. Cox , Vadim Y. Dudkin , Hannah D. Fiji , Michael J. Kelly , Mark E. Layton , Joseph E. Pero , William D. Shipe , Justin T. Sheen
发明人: Jamie L. Bunda , Christopher D. Cox , Vadim Y. Dudkin , Hannah D. Fiji , Michael J. Kelly , Mark E. Layton , Joseph E. Pero , William D. Shipe , Justin T. Sheen
IPC分类号: C07D403/06 , C07D519/00 , C07D417/14 , C07D413/14 , C07D471/04
CPC分类号: C07D403/06 , A61K31/44 , C07D413/14 , C07D417/14 , C07D471/04 , C07D519/00
摘要: The present invention is directed to isoindolinone compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
摘要翻译: 本发明涉及可用作治疗与磷酸二酯酶10(PDE10)相关的中枢神经系统疾病的治疗剂的异吲哚啉酮化合物。 本发明还涉及这些化合物用于治疗神经和精神疾病如精神分裂症,精神病或亨廷顿病以及与纹状体功能减退或基底神经节功能障碍相关的疾病的用途。
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公开(公告)号:US20120281839A1
公开(公告)日:2012-11-08
申请号:US13100693
申请日:2011-05-04
申请人: Todd W. Arnold , Elizabeth A. Dames , Carsten D. Frehr , Michael J. Kelly , Kenneth B. Kerr , Richard V. Kisley , Eric D. Rossman , Eric B. Smith
发明人: Todd W. Arnold , Elizabeth A. Dames , Carsten D. Frehr , Michael J. Kelly , Kenneth B. Kerr , Richard V. Kisley , Eric D. Rossman , Eric B. Smith
IPC分类号: H04L9/00
CPC分类号: G06F21/602 , H04L9/088 , H04L9/0897
摘要: A computer program product for secure key management is provided. The computer program product includes a tangible storage medium readable by a processing circuit and storing instructions for execution by the processing circuit for creating a token and populating the token with key material, and binding key control information to the key material. The key control information includes information relating to usage of the key material populating one or more key usage fields that define attributes that limit actions that may be performed with the key material.
摘要翻译: 提供了一种用于安全密钥管理的计算机程序产品。 计算机程序产品包括可由处理电路读取的有形存储介质,并且存储用于由处理电路执行的用于创建令牌并用密钥材料填充令牌的指令,以及将密钥控制信息绑定到密钥材料的指令。 密钥控制信息包括关于填充一个或多个密钥使用字段的密钥材料的使用的信息,所述密钥使用字段定义限制可以用密钥材料执行的动作的属性。
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公开(公告)号:US07991891B2
公开(公告)日:2011-08-02
申请号:US11346094
申请日:2006-02-02
IPC分类号: G06F15/173
CPC分类号: G06F17/30861 , H04L67/02 , Y10S707/99933 , Y10S707/99945
摘要: Content returned by a search query is specific to a version of a product installed on or associated with the computer system requesting the search. Upon receipt of the search query, a search system accesses a persistent descriptor corresponding to a detected version of the product. The persistent descriptor may be a cookie file stored on the requesting computer system. A product detection module interrogates the computer system to identify the associated products, including the particular versions of those products. The search of a repository of general content related to the product is scoped using the persistent descriptor as a search filter in order to provide version-specific content.
摘要翻译: 搜索查询返回的内容特定于安装在请求搜索的计算机系统上或与之相关联的产品的版本。 在接收到搜索查询时,搜索系统访问对应于产品的检测版本的持久描述符。 持久性描述符可以是存储在请求计算机系统上的cookie文件。 产品检测模块询问计算机系统以识别相关产品,包括这些产品的特定版本。 使用持久描述符作为搜索过滤器来搜索与该产品相关的一般内容的存储库,以便提供版本特定的内容。
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公开(公告)号:US20110022512A1
公开(公告)日:2011-01-27
申请号:US12872929
申请日:2010-08-31
IPC分类号: G06Q40/00
CPC分类号: G06Q40/02 , G06Q40/025
摘要: Embodiments of the present invention relate to methods and apparatuses for providing, processing, and/or servicing a mortgage loan having one or more exercisable options. For example, in some embodiments, a method is provided that includes storing, in a non-transitory computer-readable medium, one or more terms of an exercisable option, where the option is incorporated into a mortgage loan, where exercising the option results in one or more terms of the mortgage loan being modified, and where one or more terms of the option are based at least partially on a non-mortgage relationship between a borrower associated with the mortgage loan and a lender associated with the mortgage loan.
摘要翻译: 本发明的实施例涉及用于提供,处理和/或提供具有一个或多个可行使选项的抵押贷款的方法和装置。 例如,在一些实施例中,提供了一种方法,其包括在非暂时性计算机可读介质中存储可行权期权的一个或多个条款,其中该期权被并入抵押贷款中,其中行使该期权的结果 抵押贷款的一个或多个条款被修改,以及期权的一个或多个条款至少部分地基于与抵押贷款相关联的借款人与与抵押贷款相关的贷款人之间的非抵押关系。
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公开(公告)号:US20100222321A1
公开(公告)日:2010-09-02
申请号:US11921352
申请日:2006-06-07
申请人: Donna J. Armstrong , Essa H. Hu , Michael J. Kelly, III , Mark E. Layton , Yiwei Li , Jun Liang , Kevin J. Rodzinak , Michael A. Rossi , Philip E. Sanderson , Jiabing Wang
发明人: Donna J. Armstrong , Essa H. Hu , Michael J. Kelly, III , Mark E. Layton , Yiwei Li , Jun Liang , Kevin J. Rodzinak , Michael A. Rossi , Philip E. Sanderson , Jiabing Wang
IPC分类号: A61K31/4375 , C07D471/14 , A61K31/496 , A61K31/519 , A61K31/506 , C07D513/04 , A61K31/501 , A61K31/5377 , A61K31/517 , A61K31/4709 , A61P35/00
CPC分类号: C07D471/14 , C07D487/14
摘要: The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.
摘要翻译: 本发明提供抑制Akt活性的取代的萘啶化合物。 特别地,所公开的化合物选择性地抑制一种或两种Akt同种型。 本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制Akt活性的方法。
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公开(公告)号:US20100199534A1
公开(公告)日:2010-08-12
申请号:US12704671
申请日:2010-02-12
CPC分类号: G09F7/18 , G09F21/04 , G09F2007/1813 , G09F2007/1865 , G09F2007/1878
摘要: A system for mounting a sign to a vehicle includes a bar connected to the vehicle. A clamp assembly includes first and second jaw members adapted to frictionally engage the bar between the first and second jaw members. At least one structural member supports the first and second jaw members. A sign assembly includes a support frame having the at least one structural member connected to the support frame. A frame member is slidably received by and releasably engaged to the support frame. A sign connected to the frame member is adapted to be positioned in each of a stowed and a deployed position.
摘要翻译: 用于将标志安装到车辆的系统包括连接到车辆的杆。 夹具组件包括适于摩擦地接合第一和第二钳口构件之间的杆的第一和第二钳口构件。 至少一个结构构件支撑第一和第二钳口构件。 标志组件包括具有连接到支撑框架的至少一个结构构件的支撑框架。 框架构件被可滑动地容纳并且可释放地接合到支撑框架。 连接到框架构件的标志适于定位在收起和展开位置中的每一个中。
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公开(公告)号:US20090327700A1
公开(公告)日:2009-12-31
申请号:US12125871
申请日:2008-05-22
申请人: Steven A. Blade , Linda Nancy Betz , Andrew Gregory Kegel , Michael J. Kelly , William Lee Terrell
发明人: Steven A. Blade , Linda Nancy Betz , Andrew Gregory Kegel , Michael J. Kelly , William Lee Terrell
IPC分类号: G06F1/24
CPC分类号: G06F21/57 , G06F21/53 , H04L9/0897
摘要: A method, an apparatus, a system, and a computer program product is presented for virtualizing trusted platform modules within a data processing system. A virtual trusted platform module along with a virtual endorsement key is created within a physical trusted platform module within the data processing system using a platform signing key of the physical trusted platform module, thereby providing a transitive trust relationship between the virtual trusted platform module and the core root of trust for the trusted platform. The virtual trusted platform module can be uniquely associated with a partition in a partitionable runtime environment within the data processing system.
摘要翻译: 提出了一种方法,装置,系统和计算机程序产品,用于虚拟化数据处理系统内的可信平台模块。 使用物理可信平台模块的平台签名密钥在数据处理系统内的物理可信平台模块内创建虚拟可信平台模块以及虚拟认证密钥,从而在虚拟可信平台模块和虚拟可信平台模块之间提供传递信任关系 信任平台的核心信任根源。 虚拟可信平台模块可以与数据处理系统内的可分区运行时环境中的分区唯一关联。
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公开(公告)号:US07380119B2
公开(公告)日:2008-05-27
申请号:US10835330
申请日:2004-04-29
申请人: Steven A. Bade , Linda Nancy Betz , Andrew Gregory Kegel , Michael J. Kelly , William Lee Terrell
发明人: Steven A. Bade , Linda Nancy Betz , Andrew Gregory Kegel , Michael J. Kelly , William Lee Terrell
IPC分类号: G06F1/24
CPC分类号: G06F21/57 , G06F21/53 , H04L9/0897
摘要: A method, an apparatus, a system, and a computer program product is presented for virtualizing trusted platform modules within a data processing system. A virtual trusted platform module along with a virtual endorsement key is created within a physical trusted platform module within the data processing system using a platform signing key of the physical trusted platform module, thereby providing a transitive trust relationship between the virtual trusted platform module and the core root of trust for the trusted platform. The virtual trusted platform module can be uniquely associated with a partition in a partitionable runtime environment within the data processing system.
摘要翻译: 提出了一种方法,装置,系统和计算机程序产品,用于虚拟化数据处理系统内的可信平台模块。 使用物理可信平台模块的平台签名密钥在数据处理系统内的物理可信平台模块内创建虚拟可信平台模块以及虚拟认证密钥,从而在虚拟可信平台模块和虚拟可信平台模块之间提供传递信任关系 信任平台的核心信任根源。 虚拟可信平台模块可以与数据处理系统内的可分区运行时环境中的分区唯一关联。
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