发明申请
- 专利标题： PURIFICATION OF POSACONAZOLE AND OF POSACONAZOLE INTERMEDIATES
- 专利标题（中）： 噻苯并噻唑和噻唑烷中间体的纯化
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申请号： US13697803申请日： 2011-05-18
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公开(公告)号： US20130211086A1公开(公告)日： 2013-08-15
- 发明人: Martin Langner , Dominic De Souza , Abhinay C. Pise , Sachin Bhuta
- 申请人： Martin Langner , Dominic De Souza , Abhinay C. Pise , Sachin Bhuta
- 申请人地址： CH Basel
- 专利权人： SANDOZ AG
- 当前专利权人： SANDOZ AG
- 当前专利权人地址： CH Basel
- 优先权： EP10163210.7 20100519
- 国际申请： PCT/EP2011/058039 WO 20110518
- 主分类号： C07D307/12
- IPC分类号： C07D307/12 ; C07D405/12
摘要：
The present invention relates to a process for the preparation of a hydrogen chloride (HCl) salt of a compound of formula (I) wherein Y1 and Y2 are independently F or Cl, preferably F, said compound of formula (I) containing the cis-isomer and the trans-isomer, wherein the process comprises (1) providing the compound of formula (I) comprised in a first suitable solvent; and (2) treating the compound of formula (I) comprised in the first suitable solvent with HCl comprised in a second suitable solvent to obtain the HCl salt of the compound of formula (I).
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