公开(公告)号：US20240343666A1

公开(公告)日：2024-10-17

申请号：US18294886

申请日：2022-09-06

申请人： INSTITUTE OF MEDICINAL BIOTECHNOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCES

发明人： Liyan YU ,  Shan CEN ,  Jianyuan ZHAO ,  Xu PANG ,  Tao ZHANG ,  Wancang LIU ,  Tao ZHANG

IPC分类号： C07C50/34 ,  A61K31/122 ,  A61K31/202 ,  A61K31/222 ,  A61K31/341 ,  A61K31/351 ,  A61K31/357 ,  A61K47/55 ,  A61P31/16 ,  C07C50/38 ,  C07C59/52 ,  C07C69/145 ,  C07D307/12 ,  C07D309/24 ,  C07D317/12 ,  C12N1/14 ,  C12R1/66

CPC分类号： C07C50/34 ,  A61K31/122 ,  A61K31/202 ,  A61K31/222 ,  A61K31/341 ,  A61K31/351 ,  A61K31/357 ,  A61K47/55 ,  A61P31/16 ,  C07C50/38 ,  C07C59/52 ,  C07C69/145 ,  C07D307/12 ,  C07D309/24 ,  C07D317/12 ,  C12N1/145 ,  C07C2603/28 ,  C12R2001/66

摘要： Disclosed in the present invention are a perinaphthenone compound and the use thereof. The compound can bind to E3 ubiquitin ligase tripartite motif 25 (TRIM25), thereby facilitating the recognition of TRIM25 to a pathogen and inducing proteasome-dependent ubiquitination degradation of the pathogen protein. The compound is expected to be used as a ligand for TRIM25 and have a broad application, for example, for preparing a PROTAC molecule. Therefore, the compound has good research and development value and application prospects.

公开(公告)号：US20240061331A1

公开(公告)日：2024-02-22

申请号：US18485674

申请日：2023-10-12

申请人： FUJIFILM Corporation

发明人： Yosuke BEKKI ,  Masafumi KOJIMA ,  Akiyoshi GOTO ,  Nishiki FUJIMAKI

IPC分类号： G03F7/004 ,  C07C25/02 ,  C07C309/42 ,  C07C381/12 ,  C07D307/00 ,  C07D307/12 ,  C07D307/33 ,  C07D309/12 ,  C07D327/06 ,  C07D333/46 ,  C07D333/76 ,  C07D493/18 ,  C08F220/18 ,  C08F220/28 ,  C08F220/38 ,  G03F7/038 ,  G03F7/039

CPC分类号： G03F7/0045 ,  C07C25/02 ,  C07C309/42 ,  C07C381/12 ,  C07D307/00 ,  C07D307/12 ,  C07D307/33 ,  C07D309/12 ,  C07D327/06 ,  C07D333/46 ,  C07D333/76 ,  C07D493/18 ,  C08F220/1806 ,  C08F220/1807 ,  C08F220/1809 ,  C08F220/281 ,  C08F220/382 ,  G03F7/038 ,  G03F7/039 ,  C07C2601/14 ,  C07C2602/42 ,  C07C2603/74

摘要： An actinic ray-sensitive or radiation-sensitive resin composition contains a compound represented by general formula (S1) and an acid decomposable resin. In the general formula (S1), Q1, Q2, Q3, Q4, and Q5 each independently represent a hydrogen atom or a substituent, provided that at least one of Q1, Q2, Q3, Q4, or Q5 represents a substituent including an aryloxy group represented by general formula (QR1), Lq1 represents a single bond or a divalent linking group; and M+ represents an organic cation. In the general formula (QR1), G1, G2, G3, G4, and G5 each independently represent a hydrogen atom or a substituent, provided that at least one of G1, G2, G3, G4, or G5 represents a substituent including an ester group; and * represents a bonding position.

公开(公告)号：US20220380496A1

公开(公告)日：2022-12-01

申请号：US17764235

申请日：2020-10-01

申请人： Borealis AG

发明人： Victor Sumerin ,  Georgy Kipiani

IPC分类号： C08F210/16 ,  C07C43/10 ,  C07D307/12 ,  C07D307/42

摘要： The present invention relates to optionally substituted 1,3-dimethoxypropanes and 3-methoxypropylamines, and more particularly to their use as internal donors in Ziegler-Natta catalysts to obtain polymers with desirable properties. The present disclosure further concerns Ziegler-Natta catalyst components comprising said optionally substituted 1,3-dimethoxypropanes and 3-methoxypropylamines, and Ziegler-Natta catalysts for olefin polymerization comprising said Ziegler-Natta catalyst components, as well as a method for preparing the same and their use in providing polyolefins.

公开(公告)号：US20210198590A1

公开(公告)日：2021-07-01

申请号：US17057874

申请日：2019-05-13

申请人： BASF SE

发明人： Martin Alexander BOHN ,  Karolin GEYER ,  Wolfgang GRABARSE ,  Markus SCHERER ,  Muriel ECORMIER ,  Jan STRITTMATTER

IPC分类号： C10M105/38 ,  C10M111/02 ,  C07D307/12

摘要： A lubricant comprising 2,5-(bishydroxymethyl) tetryhydrofuran dialkanoates This invention relates to a lubricant comprising a THF ester of the formula (I) as defined below. This invention further relates to a use of the THF ester as lubricant; and to a method for reducing friction between moving surfaces comprising the step of contacting the surfaces with the lubricant or with the THF ester.

公开(公告)号：US20180258059A1

公开(公告)日：2018-09-13

申请号：US15962044

申请日：2018-04-25

申请人： Archer Daniels Midland Company

发明人： Kenneth Stensrud ,  Chi-Cheng Ma ,  Kevin Martin

IPC分类号： C07D307/12 ,  B01J23/46 ,  C07C29/60 ,  B01J25/00 ,  B01J27/053 ,  B01J27/16 ,  B01J27/20 ,  B01J23/72 ,  C07G3/00 ,  C07C29/132 ,  C07C31/26 ,  C07C31/22 ,  C07C31/24

CPC分类号： C07D307/12 ,  B01J23/462 ,  B01J23/72 ,  B01J25/00 ,  B01J27/053 ,  B01J27/16 ,  B01J27/20 ,  C07C29/132 ,  C07C29/60 ,  C07G3/00 ,  C07C31/26 ,  C07C31/22 ,  C07C31/24

摘要： Disclosed herein are methods for synthesizing 1,2,5,6-hexanetetrol (HTO), 1,6 hexanediol (HDO) and other reduced polyols from C5 and C6 sugar alcohols or R glycosides. The methods include contacting the sugar alcohol or R-glycoside with a copper catalyst, most desirably a Raney copper catalyst with hydrogen for a time, temperature and pressure sufficient to form reduced polyols having 2 to 3 fewer hydoxy groups than the starting material. When the starting compound is a C6 sugar alcohol such as sorbitol or R-glycoside of a C6 sugar such as methyl glucoside, the predominant product is HTO. The same catalyst can be used to further reduce the HTO to HDO.

公开(公告)号：US20180162885A1

公开(公告)日：2018-06-14

申请号：US15840109

申请日：2017-12-13

申请人： Eisai R&D Management Co., Ltd.

发明人： Atsushi ENDO ,  Charles E. CHASE ,  Francis G. FANG

IPC分类号： C07F7/18 ,  C07D307/38 ,  C07D407/06 ,  C07D493/04 ,  C07D405/12 ,  C07D307/12 ,  C07D405/06

CPC分类号： C07F7/1804 ,  C07D307/12 ,  C07D307/38 ,  C07D405/06 ,  C07D405/12 ,  C07D407/06 ,  C07D493/04 ,  Y02P20/55

摘要： In general, the invention features compounds useful for the synthesis of analogs of halichondrin B, such as eribulin or pharmaceutically acceptable salts thereof, e.g., eribulin mesylate. Exemplary compounds are of formula (I), (II), or (III):

公开(公告)号：US09890131B2

公开(公告)日：2018-02-13

申请号：US15102298

申请日：2014-12-19

申请人： ARCHER DANIELS MIDLAND COMPANY

发明人： Kenneth Stensrud ,  Padmesh Venkitasubramanian

IPC分类号： C07C67/08 ,  C07D307/42 ,  C07D493/04 ,  C07C67/343 ,  C07C68/06 ,  C07D307/12

CPC分类号： C07D307/42 ,  C07C67/08 ,  C07C67/343 ,  C07C68/06 ,  C07D307/12 ,  C07D493/04

摘要： A method of preparing a glycol mono-ether or mono-acetate, or carbonate involving either one of two pathways from alkylene glycols, HMF or its reduction derivative products (i.e., FDM, bHMTHFs), is provided. In particular, according to one pathway, the alkylene glycol, HMF or FDM, bHMTHFs are reacted with a dialkyl carbonate in the presence of a deprotonating agent, in substantial absence of an extrinsic catalyst, to produce an ether, and subsequently reacting the ether with an acid base. According to the other pathway, alkylene glycols are reacted with an acetate donor in the presence of an acid, base, to generate an alkylene mono-acetate, and etherified with a carbonate in the presence of a deprotonating agent.

公开(公告)号：US09868795B2

公开(公告)日：2018-01-16

申请号：US15080108

申请日：2016-03-24

申请人： Bridgestone Corporation

发明人： Terrence E. Hogan ,  Waruna C. B. Kiridena

IPC分类号： C08F2/38 ,  C08F36/04 ,  C08F36/06 ,  C08F236/04 ,  C08F236/06 ,  C08F236/10 ,  C07D307/12 ,  B60C1/00

CPC分类号： C08F2/38 ,  B60C1/00 ,  C07B2200/09 ,  C07D307/12 ,  C08F36/04 ,  C08F4/48

摘要： An oxolanyl compound-containing composition comprising specified amounts of the meso-isomer of one or more of the oxolanyl compounds of specified structure is provided. Also provided are methods for the use of such compositions as vinyl content modifiers in polymerization processes.

公开(公告)号：US20170369461A1

公开(公告)日：2017-12-28

申请号：US15539391

申请日：2015-12-21

申请人： Firmenich SA

发明人： Valery NORMAND ,  Rutger M.T. VAN SLEEUWEN

IPC分类号： C07D307/12 ,  C07C69/003 ,  A23L27/29 ,  A23L27/20 ,  A23L2/56 ,  C07C69/44 ,  C07C45/42

CPC分类号： C07D307/12 ,  A23L2/56 ,  A23L27/2024 ,  A23L27/29 ,  A23V2002/00 ,  C07C45/42 ,  C07C69/003 ,  C07C69/38 ,  C07C69/40 ,  C07C69/44 ,  C07C69/60

摘要： Provided herein are formulations of plated powders of acetaldehyde precursors. Also provided herein are methods of making and using the powders.

公开(公告)号：US20170327480A1

公开(公告)日：2017-11-16

申请号：US15527981

申请日：2014-11-21

申请人： Archer Daniels Midland Company

发明人： Kenneth Stensrud

IPC分类号： C07D307/12 ,  C07D307/42 ,  B01J31/02

CPC分类号： C07D307/12 ,  B01J31/00 ,  B01J31/0225 ,  C07D307/42

摘要： An improved process for acid-catalyzed acylation using water-tolerant Lewis acid catalysts is described. The method involves reacting a reduction products of 5-(hydroxylmethyl)-furfural (HMF), in particular either furan-2,5-dimethanol (FDM) or bis-2,5-(hydroxymethyl)-tetrahydrofuran (bHMTHFs), with an excess of an organic acid in the presence of a Lewis acid metal triflate at a temperature and time sufficient to produce esters. The conversions of the reduction products of HMF to corresponding diesters can be quantitative with certain favored Lewis acids catalysts.