Invention Application
US20130217629A1 METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES
有权
制备含有免费CYSTEINE残留物的蛋白质的方法
- Patent Title: METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES
- Patent Title (中): 制备含有免费CYSTEINE残留物的蛋白质的方法
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Application No.: US13616608Application Date: 2012-09-14
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Publication No.: US20130217629A1Publication Date: 2013-08-22
- Inventor: George N. Cox , Daniel H. Doherty , Mary S. Rosendahl
- Applicant: George N. Cox , Daniel H. Doherty , Mary S. Rosendahl
- Applicant Address: US CO Boulder
- Assignee: BOLDER BIOTECHNOLOGY, INC.
- Current Assignee: BOLDER BIOTECHNOLOGY, INC.
- Current Assignee Address: US CO Boulder
- Main IPC: A61K38/27
- IPC: A61K38/27
Abstract:
The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form pegylated proteins.
Public/Granted literature
- US08957023B2 Methods for making proteins containing free cysteine residues Public/Granted day:2015-02-17
Information query
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