发明申请
- 专利标题： INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
- 专利标题（中）： 肾脏外部药物通道的抑制剂
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申请号： US13881008申请日： 2011-10-21
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公开(公告)号： US20130225561A1公开(公告)日： 2013-08-29
- 发明人: Haifeng Tang , Alexander Pasternak , Lihu Yang , Shawn P. Walsh , Barbara Pio , Aurash Shahripour , Nardos Teumelsan
- 申请人： Haifeng Tang , Alexander Pasternak , Lihu Yang , Shawn P. Walsh , Barbara Pio , Aurash Shahripour , Nardos Teumelsan
- 国际申请： PCT/US11/57346 WO 20111021
- 主分类号： C07D295/135
- IPC分类号： C07D295/135 ; C07D295/155 ; C07D471/08 ; C07D487/08 ; C07D271/12 ; C07D213/76 ; C07D295/15
摘要：
This invention relates to compounds having structural Formula I: and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.
公开/授权文献
- US09073882B2 Inhibitors of the renal outer medullary potassium channel 公开/授权日：2015-07-07
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