发明申请
- 专利标题： ANTIMICROBIAL 4-OXOQUINOLIZINES
- 专利标题（中）： 抗微生物4-氧化物
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申请号： US13823187申请日： 2012-01-31
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公开(公告)号： US20130252882A1公开(公告)日： 2013-09-26
- 发明人: Jutta Heim , Peter Schneider , Patrick Roussel , Daniel Milligan , Christian Bartels , Glenn Dale
- 申请人： Jutta Heim , Peter Schneider , Patrick Roussel , Daniel Milligan , Christian Bartels , Glenn Dale
- 申请人地址： CH Reinach
- 专利权人： EVOLVA SA
- 当前专利权人： EVOLVA SA
- 当前专利权人地址： CH Reinach
- 国际申请： PCT/EP12/51563 WO 20120131
- 主分类号： C07D455/02
- IPC分类号： C07D455/02 ; A61K31/506 ; A61K31/496 ; A61K38/12 ; A61K31/4375
摘要：
This invention provides novel 4-oxoquinolizine compounds and their uses for a series of broad-spectrum antibiotics having no cross-resistance to existing or emerging classes of antibiotics. In addition the novel 4-oxoquinolizine compounds are useful against CDC Category A and B pathogens The invention also provides pharmaceutical compositions comprising certain 4-oxoquinolizines in combination with subinhibitory concentrations of polymyxin B against clinical isolates which are resistant to quinolones, carbapenems and other antimicrobial agents.
公开/授权文献
- US09403818B2 Antimicrobial 4-oxoquinolizines 公开/授权日：2016-08-02
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