A system and method can support virtual machine live migration in a network. A virtual switch can be associated with a plurality of virtual functions (VFs), and wherein each said virtual function (VF) is associated with a separate virtual interface (VI) space. At least one virtual machine that is attached with a said virtual function (VF) can be associated with a virtual interface (VI), e.g. a queue pair (QP) in an Infiniband (IB) architecture. Furthermore, said at least one virtual machine operates to perform a live migration from a first host to a second host with said virtual function (VF) attached.