发明申请
US20130261140A1 TRICYCLIC HETEROCYCLES USEFUL AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS
有权
作为DIPEPTIDYL PEPTIDASE-IV抑制剂有用的三聚异戊二烯
- 专利标题： TRICYCLIC HETEROCYCLES USEFUL AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS
- 专利标题（中）： 作为DIPEPTIDYL PEPTIDASE-IV抑制剂有用的三聚异戊二烯
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申请号： US13990948申请日： 2011-12-01
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公开(公告)号： US20130261140A1公开(公告)日： 2013-10-03
- 发明人: Duane A. Burnett , Zhiqiang Zhao , David Cole , Hubert Josien , Dmitri A. Pissarnitski , Thavalakulamgar Sasikumar , Wen-Lian Wu , Martin Domalski
- 申请人： Duane A. Burnett , Zhiqiang Zhao , David Cole , Hubert Josien , Dmitri A. Pissarnitski , Thavalakulamgar Sasikumar , Wen-Lian Wu , Martin Domalski
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 国际申请： PCT/US11/62868 WO 20111201
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; C07D487/14
摘要：
The present invention is directed to novel tricyclic heterocycles of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved. I
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