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    Substituted N-Arylsulfonylheterocyclic Amines As Gamma-Secretase Inhibitors
    6.
    发明申请
    Substituted N-Arylsulfonylheterocyclic Amines As Gamma-Secretase Inhibitors 失效
    取代的N-芳基磺酰基杂环胺作为γ-分泌酶抑制剂

    公开(公告)号：US20100093695A1

    公开(公告)日：2010-04-15

    申请号：US12633311

    申请日：2009-12-08

    申请人： Hubert B. Josien ,  John W. Clader ,  Thomas A. Bara ,  Ruo Xu ,  Hongmei Li ,  Dmitri A. Pissarnitski ,  Zhiqiang Zhao

    发明人： Hubert B. Josien ,  John W. Clader ,  Thomas A. Bara ,  Ruo Xu ,  Hongmei Li ,  Dmitri A. Pissarnitski ,  Zhiqiang Zhao

    IPC分类号： A61K31/438 ,  C07D413/14 ,  A61K31/5377 ,  C07D413/12 ,  C07D487/04 ,  A61K31/55 ,  A61K31/551

    CPC分类号： C07D265/30 ,  C07D413/12 ,  C07D451/02 ,  C07D487/08

    摘要： This invention discloses novel gamma secretase inhibitors of the formula: wherein: L is —O—, —N(R6)—, —S—, —S(O)—, or —S(O2)—; R1 is selected from the group consisting of aryl and heteroaryl; R2 is selected from the group consisting of alkyl, —C(O)—Y, —X—C(O)—Y, -alkylene-X—C(O)—Y, -alkylene-C(O)—Y, -alkylene-cycloalkylene-X—C(O)—Y, -alkylene-cycloalkylene-C(O)—Y, -cycloalkylene-alkylene-X—C(O)—Y, -cycloalkylene-alkylene-C(O)—Y, -cycloalkylene-X—C(O)—Y, -cycloalkylene-C(O)—Y, -alkylene-cycloalkylene-alkylene-X—C(O)—Y, -alkylene-cycloalkylene-alkylene-C(O)—Y, aryl, and heteroaryl; R3 is selected from the group consisting of aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, arylheterocycloalkyl, and alkoxyalkyl; each R4 and R5 is independently selected from the group consisting of H and alkyl; and Y is selected from the group consisting of —NR8R9, —N(R6)—(CH2)b—NR8R9, aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, and arylheterocycloalkyl; or Y is selected from the group consisting of: One or more compounds of formula I, or formulations comprising such compounds, may be useful, e.g. in treating Alzheimer's Disease.

    摘要翻译： 本发明公开了下式的新型γ-分泌酶抑制剂：其中：L是-O - ， - N（R6） - ， - S - ， - S（O） - 或-S（O 2） - ; R 1选自芳基和杂芳基; R 2选自烷基，-C（O）-Y，-X-C（O）-Y， - 亚烷基-X-C（O）-Y， - 亚烷基-C（O）-Y， - 亚烷基 - 亚环烷基-X-C（O）-Y-亚烷基 - 亚环烷基-C（O）-Y-亚烷基 - 亚烷基-X-C（O）-Y-亚烷基 - 亚烷基-C（O） （O）-Y-亚烷基-C（O）-Y-亚烷基 - 亚环烷基 - 亚烷基-X-C（O）-Y-亚烷基 - 亚环烷基 - 亚烷基-C（O ）-Y，芳基和杂芳基; R 3选自芳基，杂芳基，烷基，环烷基，芳基烷基，芳基环烷基，杂芳基烷基，杂芳基环烷基，芳基杂环烷基和烷氧基烷基; 每个R 4和R 5独立地选自H和烷基; 并且Y选自-NR 8 R 9，-N（R 6） - （CH 2）b -NR 8 R 9，芳基，杂芳基，烷基，环烷基，芳基烷基，芳基环烷基，杂芳基烷基，杂芳基环烷基和芳基杂环烷基。 或Y选自：一种或多种式I化合物或包含该化合物的制剂可用于，例如， 治疗阿尔茨海默病。

    Flow field plates for fuel cells
    7.
    发明申请
    Flow field plates for fuel cells 有权
    用于燃料电池的流场板

    公开(公告)号：US20070048591A1

    公开(公告)日：2007-03-01

    申请号：US11511614

    申请日：2006-08-28

    申请人： Junqing Dong ,  Zhiqiang Zhao

    发明人： Junqing Dong ,  Zhiqiang Zhao

    IPC分类号： H01M8/02 ,  B32B3/00

    CPC分类号： H01M8/0247 ,  H01M8/0258 ,  H01M8/0267 ,  H01M8/04074 ,  Y10T428/24479

    摘要： This invention provides a type of cathode flow field plate for fuel cells. The cathode flow field plate comprises a cooling flow field and a reacting flow field, gas entrances, gas exits and plate ribs. Here, an end of said flow field is connected to the gas entrances. The other end is connected to the gas exits. Said cooling flow field comprises of a distributing rib. Said distributing rib is located between the gas entrances and the gas exits. There are connecting pores between said gas entrances and the distributing rib. The cathode flow field plate for fuel cells provided in this invention uses the distributing rib and the connecting pores to divide the gas into cooling gas and reacting gas. Since a single gas source is used, the only parameter subject to adjustment is the total amount of gas flow. Thus the control of the gases is relatively simple. The devices controlling the sources of the cooling gas and the reacting gas can be minimized. Therefore, the fuel cells using the flow field plate provided in this invention can be low in cost.

    摘要翻译： 本发明提供一种用于燃料电池的阴极流场板。 阴极流场板包括冷却流场和反应流场，气体入口，气体出口和板肋。 这里，所述流场的末端连接到气体入口。 另一端连接到气体出口。 所述冷却流场包括分配肋。 所述分配肋位于气体入口和气体出口之间。 在所述气体入口和分配肋之间存在连接孔。 本发明提供的用于燃料电池的阴极流场板使用分配肋和连接孔将气体分成冷却气体和反应气体。 由于使用单个气源，所以调整的唯一参数是气体流量的总量。 因此，气体的控制相对简单。 控制冷却气体源和反应气体的装置可以最小化。 因此，使用本发明提供的流场板的燃料电池的成本可以低。

    Novel gamma secretase inhibitors
    8.
    发明申请
    Novel gamma secretase inhibitors 审中-公开
    新型γ分泌酶抑制剂

    公开(公告)号：US20060004004A1

    公开(公告)日：2006-01-05

    申请号：US11098745

    申请日：2005-04-04

    申请人： Theodros Asberom ,  John Clader ,  Hubert Josien ,  Mark McBriar ,  Dmitri Pissarnitski ,  Zhiqiang Zhao

    发明人： Theodros Asberom ,  John Clader ,  Hubert Josien ,  Mark McBriar ,  Dmitri Pissarnitski ,  Zhiqiang Zhao

    IPC分类号： A61K31/5377 ,  A61K31/496 ,  A61K31/4545 ,  C07D413/14 ,  C07D41/14

    CPC分类号： C07D451/04 ,  C07D211/96 ,  C07D401/06 ,  C07D401/12 ,  C07D413/06 ,  C07D413/14 ,  C07D451/06 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08

    摘要： Gamma-secretase inhibitors of the formula: are useful in treating various neurodegenerative diseases, wherein, for example: R1 includes unsubstituted or substituted aryl or heteroaryl groups; R2 includes —C(O)—Y, -alkylene-C(O)—Y, -alkylene-cycloalkylene-C(O)—Y, -cycloalkylene-alkylene-C(O)—Y, -alkylene-cycloalkylene-alkylene-C(O)—Y, -cycloalkylene-C(O)—Y, —S(O)—Y, -alkylene-S(O)—Y, -alkylene-cycloalkylene-S(O)—Y, -cycloalkylene-alkylene-S(O)—Y, -alkylene-cycloalkylene-alkylene-S(O)—Y, -cycloalkylene-S(O)—Y, —S(O2)—Y, -alkylene-S(O2)—Y, -alkylene-cycloalkylene-S(O2)—Y, -cycloalkylene-alkylene-S(O2)—Y, -alkylene-cycloalkylene-alkylene-S(O2)—Y, and -cycloalkylene-S(O2)—Y, wherein Y is as defined herein, and each of said alkylene or cycloalkylene may be unsubstituted or substituted as provided herein; each R3 is independently includes H, alkyl, —O-alkyl, —OH, —N(R9)2, acyl, and aroyl; or the moiety (R3)2, together with the ring carbon atom to which it is shown attached in formula I, defines a carbonyl group, —C(O)—; each R3A and R3B independently includes H, or alkyl; R11 includes aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, arylheterocycloalkyl, or alkoxyalkyl. One or more of the compounds of formula I, or pharmaceutically acceptable salts, solvates, and/or esters, or compositions comprised thereof, may be used to treat, e.g., Alzheimer's Disease.

    摘要翻译： 下式的γ-分泌酶抑制剂：可用于治疗各种神经变性疾病，其中例如：R 1包括未取代或取代的芳基或杂芳基; R 2包括-C（O）-Y， - 亚烷基-C（O）-Y-亚烷基 - 亚环烷基-C（O）-Y-亚烷基 - 亚烷基-C（O） - Y， - 亚烷基 - 亚环烷基 - 亚烷基-C（O）-Y-环亚烷基-C（O）-Y，-S（O）-Y-亚烷基-S（O）-Y-亚烷基 - 亚环烷基-S （O）-Y-亚烷基 - 亚烷基-S（O）-Y-亚烷基 - 亚环烷基 - 亚烷基-S（O）-Y-亚烷基-S（O）-Y，-S（O） - 亚烷基-S（O）2 - 亚烷基 - 亚环烷基-S（O）2 - 亚烷基-S（O 2） -S（O）2 - 亚烷基 - 亚环烷基 - 亚烷基-S（O）2 - 和 - 亚环烷基-S（O 2） / Y，其中Y如本文所定义，并且所述亚烷基或亚环烷基中的每一个可以是未经取代的或如本文所提供的取代的; 每个R 3独立地包括H，烷基，-O-烷基，-OH，-N（R 9）2，酰基和 芳酰基 或其部分（R 3）2和连接在式I中的环碳原子一起定义为羰基，-C（O） - ; 每个R 3A和R 3B独立地包括H或烷基; R 11包括芳基，杂芳基，烷基，环烷基，芳基烷基，芳基环烷基，杂芳基烷基，杂芳基环烷基，芳基杂环烷基或烷氧基烷基。 一种或多种式I化合物或其药学上可接受的盐，溶剂化物和/或酯或其组合物可用于治疗，例如阿尔茨海默氏病。

    ZERO-VALENT IRON TWO-PHASE ANAEROBIC REACTOR
    10.
    发明申请
    ZERO-VALENT IRON TWO-PHASE ANAEROBIC REACTOR 有权
    零级铁两相厌氧反应器

    公开(公告)号：US20130313172A1

    公开(公告)日：2013-11-28

    申请号：US13981884

    申请日：2011-09-21

    申请人： Yaobin Zhang ,  Yiwen Liu ,  Xie Quan ,  Xusheng Meng ,  Shuo Chen ,  Zhiqiang Zhao

    发明人： Yaobin Zhang ,  Yiwen Liu ,  Xie Quan ,  Xusheng Meng ,  Shuo Chen ,  Zhiqiang Zhao

    IPC分类号： C02F3/28

    CPC分类号： C02F3/28 ,  C02F3/107 ,  C02F3/2826 ,  C02F3/286 ,  Y02E50/343 ,  Y02W10/15

    摘要： The invention, belongs to the field of wastewater treatment technology, is a two-phase anaerobic reactor enhanced by addition of zero valent iron (ZVI). In the reactor, 2˜4 ZVI-filling layers are settled in the middle of the anaerobic hydrolysis-acidification tank, the effluent of which is fed into the rear anaerobic methanogenic tank. The degradation of organics is effectively enhanced in the anaerobic hydrolysis-acidification tank with dosing of ZVI, which may produce more acetic acid that is a desired substrate for the subsequent methanogenesis. Meanwhile, the acidic environment of the hydrolysis-acidification tank is helpful for the dissolution of ZVI to maintain its activity. The reactor is reasonably designed with high performance and strong shock resistance in anaerobic treatment of various wastewaters. Tests in lab-scale showed that hydrolysis-acidification and methanogenesis in this combined system were significantly improved compared with a reference reactor without addition of ZVI.

    摘要翻译： 本发明属于废水处理技术领域，是通过添加零价铁（ZVI）增强的两相厌氧反应器。 在反应器中，将2〜4个ZVI填充层沉淀在厌氧水解酸化槽的中间，将其流出物送入后厌氧甲烷生成槽。 在ZVI给药的厌氧水解酸化槽中有机物的降解被有效地增强，这可以产生更多的乙酸，其是用于随后的甲烷生成的期望的底物。 同时，水解酸化槽的酸性环境有助于溶解ZVI以维持其活性。 在各种废水的厌氧处理中，反应器设计合理，性能好，抗冲击性强。 实验室测试结果表明，与没有添加ZVI的参比反应器相比，该组合体系中的水解酸化和甲烷生成显着改善。