发明申请
US20130274191A1 METHODS AND COMPOSITIONS FOR THERAPEUTIC MODULATION OF ALDOSTERONE LEVELS IN HEART DISEASE
审中-公开
心脏疾病中阿尔托斯酮水平的治疗方法和组合物
- 专利标题： METHODS AND COMPOSITIONS FOR THERAPEUTIC MODULATION OF ALDOSTERONE LEVELS IN HEART DISEASE
- 专利标题（中）： 心脏疾病中阿尔托斯酮水平的治疗方法和组合物
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申请号： US13877955申请日： 2011-10-05
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公开(公告)号： US20130274191A1公开(公告)日： 2013-10-17
- 发明人: Anastasios Lymperopoulos , Walter J. Koch
- 申请人： Anastasios Lymperopoulos , Walter J. Koch
- 申请人地址： US PA Philadelphia US FL Fort Lauderdale
- 专利权人： THOMAS JEFFERSON UNIVERSITY,NOVA SOUTHEASTERN UNIVERSITY
- 当前专利权人： THOMAS JEFFERSON UNIVERSITY,NOVA SOUTHEASTERN UNIVERSITY
- 当前专利权人地址： US PA Philadelphia US FL Fort Lauderdale
- 国际申请： PCT/US2011/054955 WO 20111005
- 主分类号： A61K38/08
- IPC分类号： A61K38/08 ; A61K31/41 ; A61K31/4184
摘要：
The disclosure describes the contribution of elevated levels of circulating alsosterone to heart disease and other hyperaldosteronic conditions. Since activation of beta-arrestin I (beta.arr-1) by the Angiotensin II (AngII) type 1 receptor (AT1R) mediates AngII-induced aldosterone production, beta-arrestin I (beta.arr-1) is a therapeutic target for heart disease. Specifically, the disclosure provides a beta.arr-1 protein fragment comprising the C-terminus of beta.arr-1 (beta.arr1ct; SEQ ID NO:3), compositions containing this protein fragment, and methods of using this protein fragment to reduce elevated levels of aldosterone in heart disease and other hyperaldosteronic conditions by inhibition of beta-arrestin (beta.arr-1). These compositions and methods are of therapeutic benefit in chronic heart failure and progression to heart failure after myocardial infarction (MI). Additionally, the invention provides an AngII peptide analog (SEQ ID NO:4), compositions containing this analog, and methods of using this analog for stimulation of beta.arr-1 activity and aldosterone production.
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