发明申请
US20130274329A1 PLEUROMUTILIN DERIVATIVES FOR USE IN THE TREATMENT OF DISEASES MEDIATED BY MICROBES
有权
用于治疗由MICROBES介导的疾病的胰岛素衍生物
- 专利标题： PLEUROMUTILIN DERIVATIVES FOR USE IN THE TREATMENT OF DISEASES MEDIATED BY MICROBES
- 专利标题（中）： 用于治疗由MICROBES介导的疾病的胰岛素衍生物
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申请号： US13821446申请日： 2011-08-11
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公开(公告)号： US20130274329A1公开(公告)日： 2013-10-17
- 发明人: Rosemarie Riedl , Klaus Thirring , Werner Heilmayer
- 申请人： Rosemarie Riedl , Klaus Thirring , Werner Heilmayer
- 申请人地址： AT Wien
- 专利权人： NABRIVA THERAPEUTICS AG
- 当前专利权人： NABRIVA THERAPEUTICS AG
- 当前专利权人地址： AT Wien
- 优先权： EP10450143.2 20100909
- 国际申请： PCT/AT11/00342 WO 20110811
- 主分类号： C07C323/52
- IPC分类号： C07C323/52
摘要：
Compounds selected from the group of N-unsubstituted or N-alkylated or N-acylated 14-O-[(amino(C0-4)alkyl-hydroxy-cycloalkyl- or bicycloalkylsulfanyl)-acetyl]-mutilins which are 14-O-[(amino(C0-4)alkyl-hydroxy-cyclobutylsulfanyl)-acetyl]-mutilins, 14-O-[(amino(C0-4)alkyl-hydroxy-cyclopentylsulfanyl)-acetyl]-mutilins, 14-O-[(amino(C0-4)alkyl-hydroxy-cycloheptylsulfanyl)-acetyl]-mutilins, 14-O-[(amino(C0-4)alkyl-hydroxy-cyclooctylsulfanyl)-acetyl]-mutilins, or 14-O-[(amino(C0-4)alkyl-hydroxy-bicycloalkylsulfanyl)-acetyl]-mutilins, optionally in the form of a salt and/or a solvate, a pharmaceutical compositions comprising such compounds and their use as pharmaceuticals, e.g. for the treatment of microbial infections and for the treatment of acne, optionally in combination with other pharmaceutically active agents.
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