发明申请
- 专利标题： LIQUID FORMULATIONS OF LONG ACTING INTERFERON ALPHA CONJUGATE
- 专利标题（中）： 长效干扰素ALPHA联合液的液体制剂
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申请号： US13881976申请日： 2011-10-26
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公开(公告)号： US20130287734A1公开(公告)日： 2013-10-31
- 发明人: Dae Seong Im , Jae Min Lee , Jong Soo Lee , Sung Min Bae , Se Chang Kwon
- 申请人： Dae Seong Im , Jae Min Lee , Jong Soo Lee , Sung Min Bae , Se Chang Kwon
- 申请人地址： KR Hwaseong-si, Gyeonggi-do
- 专利权人： HANMI SCIENCE CO., LTD.
- 当前专利权人： HANMI SCIENCE CO., LTD.
- 当前专利权人地址： KR Hwaseong-si, Gyeonggi-do
- 优先权： KR10-2010-0104383 20101026
- 国际申请： PCT/KR2011/008038 WO 20111026
- 主分类号： A61K47/26
- IPC分类号： A61K47/26 ; A61K47/48 ; A61K38/21
摘要：
Disclosed is a liquid formulation in which a long-acting INFα conjugate that has improved in vivo duration and stability can be stored stably for a long period of time. It comprises a stabilizer comprising a buffer, a sugar alcohol, a non-ionic surfactant and an isotonic agent. Being free of human serum albumin and other potential factors harmful to the body, the liquid formulation is free of concerns about viral infections and guarantees excellent storage stability to long-acting INFα conjugates.