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公开(公告)号：US11872283B2
公开(公告)日：2024-01-16
申请号：US16506717
申请日：2019-07-09
发明人： Sung Youb Jung , Dae Jin Kim , Sung Hee Park , Young Eun Woo , In Young Choi , Se Chang Kwon
CPC分类号： A61K45/06 , A61K38/26 , A61K47/60 , A61K47/68 , A61K47/6801 , A61K47/6811 , A61K47/6889 , C07K14/575 , A61K38/00 , C07K2319/30
摘要： The present invention relates to a conjugate comprising oxyntomodulin, an immunoglobulin Fc region, and non-peptidyl polymer wherein the conjugate being obtainable by covalently linking oxyntomodulin to immunoglobulin Fc region via non-peptidyl polymer, and a pharmaceutical composition for the prevention or treatment of obesity comprising the conjugates. The conjugate comprising oxyntomodulin and the immunoglobulin Fc of the present invention reduces food intake, suppresses gastric emptying, and facilitates lipolysis without side-effects, unlike native oxyntomodulin, and also shows excellent receptor-activating effects and long-term sustainability, compared to native oxyntomodulin. Thus, it can be widely used in the treatment of obesity with safety and efficacy.
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公开(公告)号：US11168109B2
公开(公告)日：2021-11-09
申请号：US14383334
申请日：2013-03-08
发明人： Myung Hyun Jang , Min Young Kim , Jong-soo Lee , Dae Jin Kim , Sung Min Bae , Se Chang Kwon
摘要： Disclosed is a method for the preparation of a complex in which a physiologically active polypeptide is covalently bonded to an immunoglobulin constant region via a non-peptidyl linker. The method is characterized by the employment of a reducing agent, by which conventional problems of low production yield and modification of the polypeptide can be overcome. The physiologically active polypeptide-non-peptidyl polymer-immunoglobulin constant region complex can be produced with high purity and yield as well as at low cost. Thus, the method is industrially useful. Moreover, by exhibiting a prolonged action profile, the physiologically active polypeptide-non-peptidyl polymer-immunoglobulin constant region complex can be effectively used for developing long-acting formulations of physiologically active polypeptides which have improved drug compliance.
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公开(公告)号：US10363320B2
公开(公告)日：2019-07-30
申请号：US15636160
申请日：2017-06-28
发明人： Sung Youb Jung , Dae Jin Kim , Sung Hee Park , Young Eun Woo , In Young Choi , Se Chang Kwon
摘要： The present invention relates to a conjugate comprising oxyntomodulin, an immunoglobulin Fc region, and non-peptidyl polymer wherein the conjugate being obtainable by covalently linking oxyntomodulin to immunoglobulin Fc region via non-peptidyl polymer, and a pharmaceutical composition for the prevention or treatment of obesity comprising the conjugates. The conjugate comprising oxyntomodulin and the immunoglobulin Fc of the present invention reduces food intake, suppresses gastric emptying, and facilitates lipolysis without side-effects, unlike native oxyntomodulin, and also shows excellent receptor-activating effects and long-term sustainability, compared to native oxyntomodulin. Thus, it can be widely used in the treatment of obesity with safety and efficacy.
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公开(公告)号：US10272159B2
公开(公告)日：2019-04-30
申请号：US14327064
申请日：2014-07-09
发明人： Sung Youb Jung , Jin Sun Kim , Geun Hee Yang , Se Chang Kwon , Gwan Sun Lee
IPC分类号： A61K47/68 , C07K14/61 , C07K14/505 , C07K14/535 , C07K14/56 , C07K19/00 , C07K16/46
摘要： Disclosed is an IgG Fc fragment useful as a drug carrier. A recombinant vector expressing the IgG Fc fragment, a transformant transformed with the recombinant vector, and a method of preparing an IgG Fc fragment are disclosed. When conjugated to a certain drug, the IgG Fc fragment improves the in vivo duration of action of the drug and minimizes the in vivo activity reduction of the drug.
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公开(公告)号：US20180344866A1
公开(公告)日：2018-12-06
申请号：US16045511
申请日：2018-07-25
发明人： Hyung Kyu LIM , Hyun Uk KIM , Sung Hee HONG , Sung Min BAE , Se Chang KWON
IPC分类号： A61K47/68 , A61K47/10 , C07K14/61 , A61K47/26 , A61K47/12 , A61K47/02 , A61K38/27 , A61K9/08 , A61K9/00
CPC分类号： A61K47/6803 , A61K9/0019 , A61K9/08 , A61K38/27 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/68 , A61K47/6811 , C07K14/61 , C07K2319/30
摘要： A liquid formulation of highly concentrated long-acting human growth hormone conjugate contains a pharmaceutically effective amount of the long-acting human growth hormone conjugate in which human growth hormone (hGH) is linked to an immunoglobulin Fc region, and an albumin-free stabilizer, said stabilizer comprising a buffer, a non-ionic surfactant, a sugar alcohol, and sodium chloride as an isotonic agent. A method for preparing the same is provided.
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公开(公告)号：US09944688B2
公开(公告)日：2018-04-17
申请号：US14123258
申请日：2012-06-01
申请人： Sung In Lim , Myung Hyun Jang , Dae Jin Kim , Sung Youb Jung , Se Chang Kwon
发明人： Sung In Lim , Myung Hyun Jang , Dae Jin Kim , Sung Youb Jung , Se Chang Kwon
IPC分类号： A61K47/48 , A61K38/28 , A61K47/30 , A61P3/10 , C07K14/62 , A61K47/60 , A61K47/52 , A61K47/69
CPC分类号： C07K14/62 , A61K38/28 , A61K47/52 , A61K47/60 , A61K47/6921
摘要： The present invention relates to a non-peptidyl polymer-insulin multimer comprising two or more of a non-peptidyl polymer-insulin conjugate prepared by linking a non-peptidyl polymer and insulin via a covalent bond, in which the conjugates are complexed with cobalt ion to form a multimer, a method and kit for the preparation of the multimer, a pharmaceutical composition for the prevention or treatment of diabetes comprising the multimer as an active ingredient, and a method for preventing or treating diabetes by administering the composition to a subject.
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公开(公告)号：US09694007B2
公开(公告)日：2017-07-04
申请号：US13576338
申请日：2011-01-18
申请人： Jong Soo Woo , Jae Hyun Park , Yong Il Kim , Young Jun Na , Min Jung Kim , Yun Ah Lee
发明人： Jong Soo Woo , Jae Hyun Park , Yong Il Kim , Young Jun Na , Min Jung Kim , Yun Ah Lee
IPC分类号： A61K9/28 , A61K31/495 , A61K9/24 , A61K31/137
CPC分类号： A61K31/495 , A61K9/209 , A61K31/137 , A61K2300/00
摘要： An oral complex composition which comprises (i) a core comprising a swellable hydrogel-forming agent and pseudoephedrine, or a pharmaceutically acceptable salt thereof; (ii) a first coating layer encasing the core which comprises a water-soluble substance; and (iii) a second coating layer deposited on the first coating layer which comprises levocetirizine or a pharmaceutically acceptable salt thereof together with polyvinylalcohol, povidone, polyvinylalcohol-polyethyleneglycol graft copolymer or a mixture thereof, has an improved levocetirizine releasing rate and does not show a delayed release behavior even after a long storage period. Accordingly, the inventive oral complex composition is useful for treating perennial or seasonal allergic diseases including nasal obstruction, sneezing, and rhinorrhea.
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公开(公告)号：US09669105B2
公开(公告)日：2017-06-06
申请号：US13881976
申请日：2011-10-26
申请人： Dae Seong Im , Jae Min Lee , Jong Soo Lee , Sung Min Bae , Se Chang Kwon
发明人： Dae Seong Im , Jae Min Lee , Jong Soo Lee , Sung Min Bae , Se Chang Kwon
CPC分类号： A61K47/48415 , A61K9/0019 , A61K38/212 , A61K47/26 , A61K47/68 , A61K47/6813 , C07K14/56 , C07K16/46 , C07K2319/30
摘要： Disclosed is a liquid formulation in which a long-acting INFα conjugate that has improved in vivo duration and stability can be stored stably for a long period of time. It comprises a stabilizer comprising a buffer, a sugar alcohol, a non-ionic surfactant and an isotonic agent. Being free of human serum albumin and other potential factors harmful to the body, the liquid formulation is free of concerns about viral infections and guarantees excellent storage stability to long-acting INFα conjugates.
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公开(公告)号：US09394560B2
公开(公告)日：2016-07-19
申请号：US14384015
申请日：2013-03-12
发明人： Yong Ho Huh , Euh Lim Oh , Sung Youb Jung , Se Chang Kwon
摘要： Disclosed is a method of culturing E. coli cells for high density, comprising a cell growth step and an expression induction step by which a maximum of cell mass can be obtained with the concomitant maximum expression of a recombinant protein. E. coli transformed to produce a recombinant protein of interest can be grown at a high concentration using the culturing method of the present invention. Therefore, the method increases the productivity of cells as well as the production yield of the recombinant protein, and can be widely applied to the effective production of recombinant proteins.
摘要翻译： 公开了一种高密度培养大肠杆菌细胞的方法，包括细胞生长步骤和表达诱导步骤，通过该步骤可以通过重组蛋白的伴随最大表达获得最大的细胞团数。 利用本发明的培养方法可以转化生产重组蛋白质的大肠杆菌以高浓度生长。 因此，该方法提高了细胞的生产力以及重组蛋白的产量，可广泛应用于重组蛋白的有效生产。
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10.发明授权Long-acting human follicle-stimulating hormone formulation using immunoglobulin fragment 有权使用免疫球蛋白片段的长效人卵泡刺激素制剂公开(公告)号：US09186415B2
公开(公告)日：2015-11-17
申请号：US13638860
申请日：2011-04-04
申请人： Chang Hwan Kim , Sung Kap Hong , Byung Sun Lee , Soo Young Kwak , Mi Ji Lee , In Young Choi , Se Chang Kwon
发明人： Chang Hwan Kim , Sung Kap Hong , Byung Sun Lee , Soo Young Kwak , Mi Ji Lee , In Young Choi , Se Chang Kwon
CPC分类号： A61K47/48215 , A61K47/60 , A61K47/68
摘要： The present invention relates to a long-acting human follicle-stimulating hormone formulation having improved in vivo duration and stability, comprising a human follicle-stimulating hormone conjugate that is prepared by covalently linking human follicle-stimulating hormone with an immunoglobulin Fc region via a non-peptidyl polymer, and a preparation method thereof. The long-acting human follicle-stimulating hormone formulation of the present invention maintains in vivo activity of human follicle-stimulating hormone at a relatively high level and remarkably increases the serum half-life thereof.
摘要翻译： 本发明涉及具有改善的体内持续时间和稳定性的长效促卵泡激素制剂，其包含人促卵泡激素缀合物，其通过非激素共价连接人卵泡刺激激素与免疫球蛋白Fc区而制备 - 肽基聚合物及其制备方法。 本发明的长效人促卵泡激素制剂在较高水平维持人卵泡刺激激素的体内活性，并且显着增加其血清半衰期。
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