发明申请
US20130303517A1 QUINOXALINES AND AZA-QUINOXALINES AS CRTH2 RECEPTOR MODULATORS
有权
喹唑啉和AZA-喹唑啉作为CRTH2受体调节剂
- 专利标题： QUINOXALINES AND AZA-QUINOXALINES AS CRTH2 RECEPTOR MODULATORS
- 专利标题（中）： 喹唑啉和AZA-喹唑啉作为CRTH2受体调节剂
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申请号： US13996361申请日： 2011-12-19
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公开(公告)号： US20130303517A1公开(公告)日： 2013-11-14
- 发明人: Christopher W. Boyce , Sylvia Joanna Degrado , Xiao Chen , Jun Qin , Robert D. Mazzola, JR. , Younong Yu , Kevin D. McCormick , Anandan Palani , Dong Xiao , Robert George Aslanian , Jie Wu , Ashwin Umesh Rao , Phieng Siliphaivanh , Joey L. Methot , Hongjun Zhang , Elizabeth Helen Kelley , William Colby Brown , Qin Jiang , Jolicia Polivina Gauuan , Andrew J. Leyhane , Purakkattle Johny Biju , Pawan K. Dhondi , Li Dong , Salem Fevrier , Xianhai Huang , Henry M. Vaccaro
- 申请人： Christopher W. Boyce , Sylvia Joanna Degrado , Xiao Chen , Jun Qin , Robert D. Mazzola, JR. , Younong Yu , Kevin D. McCormick , Anandan Palani , Dong Xiao , Robert George Aslanian , Jie Wu , Ashwin Umesh Rao , Phieng Siliphaivanh , Joey L. Methot , Hongjun Zhang , Elizabeth Helen Kelley , William Colby Brown , Qin Jiang , Jolicia Polivina Gauuan , Andrew J. Leyhane , Purakkattle Johny Biju , Pawan K. Dhondi , Li Dong , Salem Fevrier , Xianhai Huang , Henry M. Vaccaro
- 国际申请： PCT/US11/65716 WO 20111219
- 主分类号： C07D241/42
- IPC分类号： C07D241/42 ; C07D401/12 ; C07D403/06 ; C07D471/04 ; A61K31/4985 ; C07D471/10 ; C07D405/12 ; C07D401/14 ; A61K31/506 ; A61K31/55 ; C07D417/12 ; C07D498/04 ; C07D491/107 ; A61K45/06 ; A61K31/498
摘要：
The invention provides certain quinoxalines and aza-quinoxalines of the Formula (I), and their pharmaceutically acceptable salts, wherein J1, J2, R1, R2, R3, R22, Ra, Rb, Rc, Rd, X, Y, b, n, and q are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function.
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