A method for preparing high-grade and casual fabric with special leather feel using a corn-based fiber that comprises the steps of: 1) selecting 0.3-0.5 D/PF ultrafine corn-based SORONA fiber from DuPont (U.S.) and 0.2-0.4 D/PF long porous bright polyester yarns as raw materials; 2) compositing by air-jet texturing: having the above raw materials composited by low tension air-jet texturing in an air texturing machine, with the tension force controlled in the range of 4.5-6.0 cN, so as to form ATY yarns with a denier number of 120-180 D; 3) weaving, which includes yarn sizing, preliminary drying, oil applying and plain weaving; 4) dyeing and finishing, which include treating a fabric by pre-treating, presetting, splitting and alkali detaching, water washing and dehydrating, dyeing, water repellent treatment, instant ultrahigh temperature treatment, and one-sided lustering. The fabric prepared according to the present invention has the following advantages: it has smooth surface and soft feel, is waterproof, antifouling and antistatic, has excellent anti-wrinkle properties, has the luster and texture of natural leather material, and is good in breathability and moisture penetrability, it can be used for making both winter clothing and summer clothing, can be water-washed or dry cleaned, it has no need for ironing, is easy to care for, etc.