发明申请
- 专利标题： STABILITY AND POTENCY OF HEMAGGLUTININ
- 专利标题（中）： HEMAGGLUTININ的稳定性和耐药性
-
申请号： US13838796申请日： 2013-03-15
-
公开(公告)号： US20130315955A1公开(公告)日： 2013-11-28
- 发明人: Kathleen Holtz , Erin Matthews , David Rhodes , Indresh Srivastava
- 申请人： Kathleen Holtz , Erin Matthews , David Rhodes , Indresh Srivastava
- 申请人地址： US CT Meriden
- 专利权人： Protein Sciences Corporation
- 当前专利权人： Protein Sciences Corporation
- 当前专利权人地址： US CT Meriden
- 主分类号： A61K39/145
- IPC分类号： A61K39/145
摘要：
The present invention relates to methods of improving the stability and maintaining the potency of recombinant hemagglutinin formulations, in particular, recombinant influenza hemagglutinin (rHA). In particular, Applicants have shown that the stability of rHA formulations may be significantly improved by mutating cysteine residues or by formulating with a reducing agent and sodium citrate.