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公开(公告)号：US20130315955A1
公开(公告)日：2013-11-28
申请号：US13838796
申请日：2013-03-15
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K9/0019 , A61K39/12 , A61K47/10 , A61K47/12 , A61K47/20 , C07K14/11 , C12N2760/16134
摘要： The present invention relates to methods of improving the stability and maintaining the potency of recombinant hemagglutinin formulations, in particular, recombinant influenza hemagglutinin (rHA). In particular, Applicants have shown that the stability of rHA formulations may be significantly improved by mutating cysteine residues or by formulating with a reducing agent and sodium citrate.
摘要翻译： 本发明涉及改善重组血凝素制剂，特别是重组流感血凝素（rHA）的稳定性和维持效力的方法。 特别地，申请人已经表明，通过突变半胱氨酸残基或通过用还原剂和柠檬酸钠配制可以显着改善rHA制剂的稳定性。
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公开(公告)号：US20060104208A1
公开(公告)日：2006-05-18
申请号：US10986966
申请日：2004-11-12
申请人： Anthony Walker , Darren Smith , Russell Huonder , David Rhodes , Kam Wong , Srikanth Natarajan
发明人： Anthony Walker , Darren Smith , Russell Huonder , David Rhodes , Kam Wong , Srikanth Natarajan
CPC分类号： H04L41/0631 , H04L41/0677 , H04L43/10
摘要： A method and system for reducing fault analysis times in a network having a plurality of pollable objects. Poll responses are received from pollable objects, priorities are assigned to each received poll response in accordance with one or more of a received poll response value, a pollable object status and a type of pollable object, and the assigned priorities are processed and to determine any fault locations, wherein a pollable object with a higher priority is processed before a second pollable object with a lower priority. A status manager is operable to receive poll responses from one or more of the pollable objects, a status analyzer is operable to assign, in conjunction with one or more analyzers, priorities to each received poll response in accordance with the received poll response value, a pollable object status and a type of pollable object, and analyzers coupled the status analyzer use the assigned priorities and the corresponding received poll responses to determine a fault location.
摘要翻译： 一种用于减少具有多个可轮询对象的网络中的故障分析时间的方法和系统。 从可轮询对象接收到轮询响应，根据接收到的轮询响应值，可轮询对象状态和可轮询对象的类型中的一个或多个，将优先级分配给每个接收到的轮询响应，并且分配的优先级被处理并且确定任何 故障位置，其中具有较高优先级的可轮询对象在具有较低优先级的第二可批查对象之前被处理。 状态管理器可操作以从一个或多个可轮询对象接收轮询响应，状态分析器可操作以根据所接收的轮询响应值，与一个或多个分析器一起分配每个接收到的轮询响应的优先级， 可轮询对象状态和可轮询对象的类型，并且耦合状态分析器的分析器使用分配的优先级和相应的接收到的轮询响应来确定故障位置。
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公开(公告)号：US06918753B2
公开(公告)日：2005-07-19
申请号：US10278782
申请日：2002-10-24
申请人： Georg Nemeskeri , Brent Fay , Rodney Publicover , Stephen Fitzgerald , Colin Veinot , Gary Holmes , David Rhodes , Denis Savoie , Randy Steadman , Peter Haase
发明人： Georg Nemeskeri , Brent Fay , Rodney Publicover , Stephen Fitzgerald , Colin Veinot , Gary Holmes , David Rhodes , Denis Savoie , Randy Steadman , Peter Haase
CPC分类号： B29C51/20 , B29C37/0007 , B29C51/04 , B29C51/10 , B29C51/32 , B29C51/38 , B29C51/44 , B29C2791/007 , B29L2031/7136
摘要： The thermoforming press has a frame, a forming die assembly affixed to the frame, a mold-supporting table suspended to the frame under the forming die assembly, and a pair of molds mounted side by side on the mold-supporting table. A drive system is provided for imparting a pendulum movement to the mold-supporting table for alternately registering one of the molds with the forming die assembly while the other mold is positioned at a part retrieving station. The part retrieving and stacking mechanism has horizontal and angular displacements only as the vertical component of the retrieving motion is provided by the pendulum system. Spring discs are mounted between the forming die assembly and the press platen to control the forces generated between the forming die assembly and each mold.
摘要翻译： 热成型压机具有框架，固定在框架上的成型模具组件，在成型模具组件下方悬挂于框架的模具支撑台以及并排安装在模具支撑台上的一对模具。 提供驱动系统，用于向模具支撑台施加摆动运动，以便在成型模具组件中交替地登记一个模具，而另一个模具位于部件检索站。 只有当摆锤系统提供检索运动的垂直分量时，部件回收和堆叠机构才具有水平和角位移。 弹簧盘安装在成形模具组件和压板之间，以控制成形模具组件和每个模具之间产生的力。
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公开(公告)号：US4832202A
公开(公告)日：1989-05-23
申请号：US51660
申请日：1987-05-19
申请人： Alec T. Newman , David Rhodes , Bryan C. Lack
发明人： Alec T. Newman , David Rhodes , Bryan C. Lack
IPC分类号： B65D1/26
CPC分类号： B65D1/265
摘要： A nestable container which is constructed so that when formed into a stack the ribs formed in the outer surface of one container rest on an inner shoulder of the container below it in the stack, the angle of inclination of the ribs being the same as the angle of inclination of the inner surface of the side wall portion which it abuts of the container below it in the stack, and the outer surface of one container adjacent to the base engaging the inner surface of the side wall portion of the container below it in the stack to form a powder seal. The cups when nested together to form a stack are freely rotatable one inside the other.
摘要翻译： 一种可嵌套的容器，其被构造成使得当形成为堆叠时，形成在一个容器的外表面中的肋搁置在堆叠体下方的容器的内肩上，肋的倾斜角度与角度 倾斜的侧壁部分的内表面与托盘下方的容器邻接，并且与底座相邻的一个容器的外表面在其下方的容器的侧壁部分的内表面接合在其中 堆叠形成粉末密封。 当嵌套在一起以形成堆叠的杯子可以自由地在另一个内部旋转。
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公开(公告)号：US20130074559A1
公开(公告)日：2013-03-28
申请号：US13520522
申请日：2010-12-03
申请人： Stephen John Cox , David Rhodes
发明人： Stephen John Cox , David Rhodes
IPC分类号： B21D53/36
摘要： A method of manufacturing a resilient rail clip comprises bending a rod, made of metal having a hardness value falling within a known hardness value range, into a predetermined shape and then subjecting the bent rod to a cold setting process in order to induce in the bent rod a predetermined amount of permanent set (S). One cold setting process comprises applying a first load (F0) to part of the bent rod so as to cause a first amount of deflection of that part of the bent rod, which first load (F0) is a predetermined load having a value equal to or greater than that required to reach the yield point of metal having the highest hardness value in the said hardness value range, measuring the first amount of deflection (dX) of the said part of the bent rod achieved by applying the predetermined first load (F0), determining, on the basis of the measured deflection amount (dX), either (i) a second load (F0+ΔFX), which, when applied to the said part of the bent rod, will cause the bent rod to acquire the predetermined amount of permanent set (S), or (ii) a second amount of deflection (dX+ΔdX) of the said part of the bent rod required in order to bring about in the bent rod the predetermined amount of permanent set (S), and applying the second load (F0+ΔFX) to the said part of the bent rod or deflecting the said part of the bent rod by the determined second amount of deflection (dX+ΔdX). An alternative cold setting process comprises deflecting part of the bent rod by a predetermined first amount (d0) by applying a first load (FX) having a value equal to or greater than that required to reach the yield point of metal having the highest hardness value in the said hardness value range, measuring the amount of the first load (FX) required to achieve the predetermined first amount of deflection (d0), determining, on the basis of the measured load, either (i) a second deflection amount (d0+ΔdX) required in order to bring about in the bent rod the predetermined amount of permanent set (S), or (ii) a second load (FX+ΔFX), which, when applied to the said part of the bent rod, will cause the bent rod to acquire the predetermined amount of permanent set (S), and deflecting the said part of the bent rod by the determined second deflection amount (d0+ΔdX) or applying the determined second load (FX+ΔFX) to the said part of the bent rod.
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公开(公告)号：US20070196602A1
公开(公告)日：2007-08-23
申请号：US11357231
申请日：2006-02-17
CPC分类号： D21H21/16 , B31C11/04 , Y10T428/13 , Y10T428/1303 , Y10T428/1307 , Y10T428/139 , Y10T428/1393 , Y10T428/28
摘要： A wound paperboard tube having enhanced burst strength in high-moisture conditions up to and including complete and prolonged submersion in liquid water comprises a plurality of paperboard plies formed from a pulp comprising papermaking furnish and an effective amount of a size such that the paperboard plies have reduced moisture add-on when submerged in water, relative to paperboard plies formed from a pulp comprising the identical furnish but without the size. The plies are wound one upon another about an axis of the tube and adhered together with a water-resistant adhesive comprising a polyvinyl composition containing a cross-linking agent for inducing cross-linking of the adhesive.
摘要翻译： 在高湿度条件下具有增强的破裂强度并且包括完全和长期浸没在液态水中的卷绕纸板管包括多个纸浆层，其由包含造纸配料的纸浆形成，并且有效量的尺寸使得纸板层具有 浸没在水中时相对于由包含相同配料而不具有尺寸的纸浆形成的纸板帘布层减少水分附着物。 这些层绕管的轴线一个接一个地缠绕，并用包含含有用于引起粘合剂交联的交联剂的聚乙烯基化合物的防水粘合剂粘合在一起。
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公开(公告)号：US20060060008A1
公开(公告)日：2006-03-23
申请号：US10947861
申请日：2004-09-23
申请人： Xiaokai Niu , David Rhodes , Jason Stephens , Yiming Wang
发明人： Xiaokai Niu , David Rhodes , Jason Stephens , Yiming Wang
CPC分类号： G01N3/20 , B65H18/00 , B65H29/62 , B65H2408/40 , B65H2701/18442 , G01N33/34 , G01N2203/0033 , G01N2203/0274
摘要： A test device includes a stationary web roll support assembly comprising a base and a pair of core supports spaced apart and affixed to the base with the core supports projecting upwardly from the base, the core supports structured and arranged to engage opposite ends of a core of a web roll so as to support the web roll. The test device also includes a movable weight load simulating assembly comprising a flexible belt having opposite ends, and a belt holder structured and arranged to secure the opposite ends of the belt to the belt holder with the belt forming a generally U-shaped loop about an outer surface of the web roll intermediate the opposite ends of the core. Movement of the belt holder away from the stationary web roll support assembly causes the belt to exert a load on the web roll, simulating weight load on the core and core supports.
摘要翻译： 测试装置包括固定卷筒纸支撑组件，其包括基部和间隔开并固定到基部的一对芯支撑，其中芯支撑件从基部向上突出，芯支撑件被构造和布置成与芯部的芯的相对端接合 卷筒纸卷以支撑卷材卷。 测试装置还包括可移动重量负载模拟组件，其包括具有相对端的柔性带和构造和布置成将带的相对端固定到带保持器的带保持器的带保持器，其中带形成大致U形环 腹板的外表面在芯的相对端之间。 皮带保持架远离固定卷筒纸支承组件的运动导致皮带在卷材卷筒上施加载荷，从而模拟芯部和芯部支撑件上的重量。
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公开(公告)号：US4215801A
公开(公告)日：1980-08-05
申请号：US854243
申请日：1977-11-23
申请人： Alec T. Newman , David Rhodes
发明人： Alec T. Newman , David Rhodes
CPC分类号： A47J31/404 , G07F13/10 , Y10T137/85986
摘要： The invention provides a valve for dispensing material from a hopper. The valve comprises a body defining a passage way, a generally L-shaped valve member pivotally mounted to one side of the passageway such that the inner faces of the arms of the valve member can engage respective ones of a pair of spaced back to back valve seats disposed in the passageway so that in use with the downstream of the two arms closing the passageway by engaging the downstream valve seat a charge of material in the hopper can be received between the two arms and dispensed when the valve member is rotated to open the passageway by the downstream arm and subsequently close it by the upstream arm engaging the upstream valve seat, flow through the passageway being substantially obstructed by the upstream arm as the valve member is returend to close the passageway by the downstream arm.
摘要翻译： 本发明提供一种用于从料斗分配材料的阀。 阀包括限定通道的主体，大致L形的阀构件，枢转地安装到通道的一侧，使得阀构件的臂的内表面可以接合一对间隔开的背靠背阀中的相应的一个 设置在通道中的座椅，使得在使用中，两个臂的下游通过接合下游阀座而关闭通道，料斗中的物料可以被容纳在两个臂之间，并且当阀构件旋转以打开时 通过下游臂并随后通过与上游阀座接合的上游臂将其封闭，当阀构件旋转以通过下游臂关闭通道时，流过通道被上游臂基本上阻挡。
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公开(公告)号：US06499667B1
公开(公告)日：2002-12-31
申请号：US09856013
申请日：2001-05-16
申请人： David Rhodes , David John Gosling
发明人： David Rhodes , David John Gosling
IPC分类号： E01B938
CPC分类号： E01B9/34 , E01B2205/00
摘要： In a railway sleeper assembly, a pair of rail insulators (3) designed for use with a steel railway sleeper (1) which includes at the opposite sides of each intended rail location thereon a pair of openings (6) for receiving the respective stems (8) of a pair of shoulders (4), are each operatively disposed, when in use, between a foot of the rail (2) and the respective proximate shoulder (4). Each insulator (3) includes a member (11) which, when the insulator is in use, operatively extends below a top surface of the sleeper (1) and into the associated opening (6) so as to lie between the walls of that opening (6) and the stem (8) of the associated shoulder (4), thereby to retain the shoulder (4) in its operative position relative to the sleeper. The insulators (3), the shoulders (4) and a pair of rail clips (5) are preloaded onto, and are preassembled with, the sleeper (1) at a location remote from the track site, such that the entire assembly, with the rail clips (5) mounted in a preload position on the shoulders (4), can then be transported as a unit to the track site while the various components are retained on the sleeper (1) in their operative positions and are secure against falling off the sleeper (1) during transit of the assembly to the track site.
摘要翻译： 在铁路枕木组件中，一对设计用于与铁路轨枕（1）一起使用的轨道绝缘体（3），其在每个预期轨道位置的相对侧上包括一对用于接收相应杆的开口（6） 一对肩部（4）的每个肩部（8）在使用时分别在轨道（2）的脚和相应的邻近肩部（4）之间操作地设置。 每个绝缘体（3）包括构件（11），当绝缘体在使用时，其可操作地延伸到枕木（1）的顶表面下方并进入相关联的开口（6）中，以便位于该开口的壁之间 （6）和相关联的肩部（4）的杆（8），从而将肩部（4）相对于卧铺器保持在其操作位置。 绝缘体（3），肩部（4）和一对导轨夹（5）在远离轨道位置的位置被预加载在枕木（1）上并与之组装，使得整个组件具有 安装在肩部（4）上的预加载位置的导轨夹（5）可以作为一个单元被运输到轨道位置，同时将各种部件保持在轨枕（1）的操作位置并且牢固抵抗下落 在组装过程中，将轨枕（1）运送到轨道位置。
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公开(公告)号：US4235352A
公开(公告)日：1980-11-25
申请号：US854241
申请日：1977-11-23
申请人： Alec T. Newman , David Rhodes
发明人： Alec T. Newman , David Rhodes
CPC分类号： A47J31/404 , G07F13/10 , Y10T137/85986
摘要： This invention provides water supply apparatus having a water reservoir serving two or more nozzles, a pump for pumping the water to the nozzles, a valve for opening and closing a respective nozzle and apparatus for varying the rate of pumping of the pump in accordance with the number of valves which are open.
摘要翻译： 本发明提供一种供水装置，其具有用于两个或多个喷嘴的储水器，用于将水泵送到喷嘴的泵，用于打开和关闭相应喷嘴的阀以及根据该喷嘴改变泵的泵送速率的装置 打开的阀门数量。
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