发明申请
- 专利标题： Use of Artemisine Derivatives and Pharmaceutical Salts Thereof
- 专利标题（中）： 使用青蒿酸衍生物及其制药盐
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申请号： US13982684申请日： 2012-01-16
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公开(公告)号： US20130317095A1公开(公告)日： 2013-11-28
- 发明人: Jianqing Mi , Ying Li , Yu Peng , Yu Zhang , Ruimin Nie , Jingjing Liu , Jin Wang , Yueying Wang , Xun Cai , Yang Li , Saijuan Chen , Zhenyi Wang
- 申请人： Jianqing Mi , Ying Li , Yu Peng , Yu Zhang , Ruimin Nie , Jingjing Liu , Jin Wang , Yueying Wang , Xun Cai , Yang Li , Saijuan Chen , Zhenyi Wang
- 申请人地址： CN Shanghai
- 专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 当前专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 当前专利权人地址： CN Shanghai
- 优先权： CN201110034201.X 20110131
- 国际申请： PCT/CN2012/070401 WO 20120116
- 主分类号： C07D493/18
- IPC分类号： C07D493/18 ; C07C57/145
摘要：
The invention demonstrates the application of an artemisinin derivative and its pharmaceutical salt. The artemisinin derivatives diarteether amine and its pharmaceutical salt inhibit the proliferation of leukemic cells, block the cell cycle of leukemic cells and induce the apoptosis of leukemic cells. Artemisinin derivatives of the present invention and its pharmaceutical salt can be used for the preparation of anti-leukemia medicines, especially for treatment of acute leukemia and, what's more, for the treatment of acute myeloid leukemia.
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