Invention Application
US20130331282A1 MARKER COMPOSITION COMPRISING S1P PROTEIN FOR PREDICTION OF RISK IN OSTEOPOROTIC FRACTURE AND OSTEOPOROSIS
审中-公开
包含S1P蛋白质的标记物组合物，用于预测OSTEOPOROTIC FRACTURE和OSTEOPOSOSIS的风险
- Patent Title: MARKER COMPOSITION COMPRISING S1P PROTEIN FOR PREDICTION OF RISK IN OSTEOPOROTIC FRACTURE AND OSTEOPOROSIS
- Patent Title (中): 包含S1P蛋白质的标记物组合物，用于预测OSTEOPOROTIC FRACTURE和OSTEOPOSOSIS的风险
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Application No.: US13865688Application Date: 2013-04-18
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Publication No.: US20130331282A1Publication Date: 2013-12-12
- Inventor: Jung Min Koh , Ghi Su Kim , Seung Hun Lee , Beom Jun Kim
- Applicant: THE ASAN FOUNDATION
- Priority: KR10-2012-0061678 20120608
- Main IPC: G01N33/92
- IPC: G01N33/92 ; C07K16/18 ; C07K14/47
Abstract:
Disclosed herein is a marker composition that includes sphingosine 1-phosphate (S1P) protein and that may be used to predict the risk of fracture or osteoporosis; a kit that includes an antibody that specifically binds to the S1P protein and that can be used to predict the risk of fracture or osteoporosis; and a method that can be used to obtain information that allows prediction of the risk of fracture or osteoporosis and includes measurements of S1P protein concentrations by measuring the binding of a S1P-specific antibody to S1P protein. The S1P protein disclosed herein is highly expressed in individuals with fracture, regardless of their bone mineral density. Accordingly, it may be useful as a biomarker of the risk of fracture or osteoporosis.
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