公开(公告)号：US20130331282A1

公开(公告)日：2013-12-12

申请号：US13865688

申请日：2013-04-18

Applicant: THE ASAN FOUNDATION

Inventor： Jung Min Koh ,  Ghi Su Kim ,  Seung Hun Lee ,  Beom Jun Kim

IPC: G01N33/92 ,  C07K16/18 ,  C07K14/47

CPC classification number: G01N33/92 ,  C07K14/47 ,  C07K16/18 ,  G01N33/6893 ,  G01N2405/08 ,  G01N2800/108

Abstract: Disclosed herein is a marker composition that includes sphingosine 1-phosphate (S1P) protein and that may be used to predict the risk of fracture or osteoporosis; a kit that includes an antibody that specifically binds to the S1P protein and that can be used to predict the risk of fracture or osteoporosis; and a method that can be used to obtain information that allows prediction of the risk of fracture or osteoporosis and includes measurements of S1P protein concentrations by measuring the binding of a S1P-specific antibody to S1P protein. The S1P protein disclosed herein is highly expressed in individuals with fracture, regardless of their bone mineral density. Accordingly, it may be useful as a biomarker of the risk of fracture or osteoporosis.

Abstract translation: 本文公开了包含鞘氨醇1-磷酸（S1P）蛋白质并可用于预测骨折或骨质疏松症风险的标记物组合物; 包括特异性结合S1P蛋白并可用于预测骨折或骨质疏松症风险的抗体的试剂盒; 以及可用于获得允许预测骨折或骨质疏松症风险的信息的方法，并且包括通过测量S1P特异性抗体与S1P蛋白的结合来测量S1P蛋白浓度。 本文公开的S1P蛋白质在具有骨折的个体中高度表达，而不管其骨矿物质密度如何。 因此，作为骨折或骨质疏松症风险的生物标志物可能是有用的。