Methods, apparatus and systems for incapacitating eccrine glands are disclosed herein. A method for incapacitating eccrine glands may comprise inserting a tissue dissecting and modifying wand (TDM) into an incision in a patient's skin. The TDM may comprise a tip having a plurality of protrusions with lysing segments positioned between the protrusions. The TDM may also comprise an energy window positioned on top of the TDM that is configured to deliver energy to incapacitate eccrine glands. After separating tissue using the lysing segment(s) to define a target region, the energy window may be activated and moved around within the target region to incapacitate eccrine glands. In some implementations, the energy window may be activated prior to separating the tissue such that the tissue is separated while eccrine glands are incapacitated within the target region.