发明申请
- 专利标题： PYRROLOPYRIDINEAMINO DERIVATIVES AS MPS1 INHIBITORS
- 专利标题（中）： 作为MPS1抑制剂的吡咯并吡啶胺衍生物
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申请号： US14004515申请日： 2012-03-14
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公开(公告)号： US20130345181A1公开(公告)日： 2013-12-26
- 发明人: Vassilios Bavetsias , Butrus Atrash , Sébastien Gaston André Naud , Peter William Sheldrake , Julian Blagg
- 申请人： Vassilios Bavetsias , Butrus Atrash , Sébastien Gaston André Naud , Peter William Sheldrake , Julian Blagg
- 申请人地址： GB London
- 专利权人： CANCER RESEARCH TECHNOLOGY LIMITED
- 当前专利权人： CANCER RESEARCH TECHNOLOGY LIMITED
- 当前专利权人地址： GB London
- 优先权： GB1104267.8 20110314
- 国际申请： PCT/GB2012/050564 WO 20120314
- 主分类号： C07D471/04
- IPC分类号： C07D471/04
摘要：
The present invention relates to the use of certain pyrrolopyridineamino derivatives (hereinafter referred to as “PPA derivatives”), particularly 1H-pyrrolo[3,2-c]pyridine-6-amino derivatives, to inhibit the spindle checkpoint function of Monospindle 1 (Mps1—also known as TTK) kinases either directly or indirectly via interaction with the Mps kinase itself. In particular, the present invention relates to PPA derivatives for use as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of the PPA derivatives, and pharmaceutical compositions comprising them. Formula (I)
公开/授权文献
- US09371319B2 Pyrrolopyridineamino derivatives as MPS1 inhibitors 公开/授权日：2016-06-21
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