Invention Application
US20130345204A1 SUBSTITUTED BICYCLIC CYCLOALKYL PYRAZOLE LACTAM ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS
审中-公开
作为MGLUR5受体的独立型调节剂的取代的双环环丙基吡唑LACTAM模拟物
- Patent Title: SUBSTITUTED BICYCLIC CYCLOALKYL PYRAZOLE LACTAM ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS
- Patent Title (中): 作为MGLUR5受体的独立型调节剂的取代的双环环丙基吡唑LACTAM模拟物
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Application No.: US13922225Application Date: 2013-06-19
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Publication No.: US20130345204A1Publication Date: 2013-12-26
- Inventor: P. Jeffrey Conn , Craig W. Lindsley , Shaun R. Stauffer , José Manuel Bartolomé-Nebreda , Susana Conde-Ceide , Gregor James Macdonald , Han Min Tong
- Applicant: Vanderbilt University
- Main IPC: C07D487/04
- IPC: C07D487/04
Abstract:
In one aspect, the invention relates to substituted bicyclic cycloalkyl pyrazole lactam analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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