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    BICYCLIC PYRAZOLE COMPOUNDS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS
    3.
    发明申请
    BICYCLIC PYRAZOLE COMPOUNDS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS 有权
    作为MGLUR5受体的独立型调节剂的双相吡唑化合物

    公开(公告)号：US20140213593A1

    公开(公告)日：2014-07-31

    申请号：US14228179

    申请日：2014-03-27

    Applicant: Vanderbilt University

    Inventor： P. Jeffrey Conn ,  Craig W. Lindsley ,  Shaun R. Stauffer ,  José Manuel Bartolomé-Nebreda ,  Susana Conde-Ceide ,  Gregor Macdonald ,  Han Min Tong ,  Carrie K. Jones

    IPC: C07D487/04

    CPC classification number: C07D487/04

    Abstract: In one aspect, the invention relates to bicyclic pyrazole compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    Abstract translation: 一方面，本发明涉及双代吡唑化合物，其衍生物和相关化合物，其可用作代谢型谷氨酸受体亚型5（mGluR5）的正变构调节剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

    SUBSTITUTED BICYCLIC ARALKYL PYRAZOLE LACTAM ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS
    4.
    发明申请
    SUBSTITUTED BICYCLIC ARALKYL PYRAZOLE LACTAM ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS 审中-公开
    作为MGLUR5受体的独立调节剂的取代的双环烷基吡唑类LACTAM模拟物

    公开(公告)号：US20130345205A1

    公开(公告)日：2013-12-26

    申请号：US13922229

    申请日：2013-06-19

    Applicant: Vanderbilt University

    Inventor： P. Jeffrey Conn ,  Craig W. Lindsley ,  Shaun R. Stauffer ,  José Manuel Bartolomé-Nebreda ,  Susana Conde-Ceide ,  Gregor James Macdonald ,  Han Min Tong ,  Manuel Jesús Alcázar-Vaca ,  José Ignacio Andrés-Gil

    IPC: C07D487/04

    CPC classification number: C07D487/04

    Abstract: In one aspect, the invention relates to substituted bicyclic aralkyl pyrazole lactam analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    Abstract translation: 一方面，本发明涉及用作代谢型谷氨酸受体亚型5（mGluR5）的正变构调节剂的取代的双环芳烷基吡唑内酰胺类似物，其衍生物和相关化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

    Substituted pyrazolo[1,5-a]pyrazines as mGluR5 receptor modulators
    6.
    发明授权
    Substituted pyrazolo[1,5-a]pyrazines as mGluR5 receptor modulators 有权
    取代的吡唑并[1,5-a]吡嗪作为mGluR5受体调节剂

    公开(公告)号：US09255103B2

    公开(公告)日：2016-02-09

    申请号：US14228179

    申请日：2014-03-27

    Applicant: Vanderbilt University

    Inventor： P. Jeffrey Conn ,  Craig W. Lindsley ,  Shaun R. Stauffer ,  José Manuel Bartolomé-Nebreda ,  Susana Conde-Ceide ,  Gregor Macdonald ,  Han Min Tong ,  Carrie K. Jones

    IPC: C07D241/38 ,  C07D487/04

    CPC classification number: C07D487/04

    Abstract: In one aspect, the invention relates to substituted pyrazolo[1,5-a]pyrazines analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    Abstract translation: 一方面，本发明涉及用作代谢型谷氨酸受体亚型5（mGluR5）的正变构调节剂的取代的吡唑并[1,5-a]吡嗪类似物，其衍生物和相关化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

    SUBSTITUTED IMIDAZOPYRIMIDIN-5(6H)-ONES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS
    9.
    发明申请
    SUBSTITUTED IMIDAZOPYRIMIDIN-5(6H)-ONES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS 审中-公开
    作为MGLUR5受体的独立调节因子的取代的咪达霉素-5（6H）

    公开(公告)号：US20140329838A1

    公开(公告)日：2014-11-06

    申请号：US14304826

    申请日：2014-06-13

    Applicant: Vanderbilt University

    Inventor： P. Jeffrey Conn ,  Craig W. Lindsley ,  Shaun R. Stauffer ,  Jose Manuel Bartolome-Nebreda ,  Gregor Macdonald ,  Susana Conde-Ceide ,  Carrie K. Jones ,  Maria Luz Martin-Martin ,  Han Min Tong

    IPC: C07D487/04

    CPC classification number: C07D487/04

    Abstract: In one aspect, the invention relates to imidazopyrimidin-5(6H)-one analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    Abstract translation: 一方面，本发明涉及可用作代谢型谷氨酸受体亚型5（mGluR5）的正变构调节剂的咪唑并嘧啶-5（6H） - 酮类似物及其衍生物和相关化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

    SUBSTITUTED BICYCLIC CYCLOALKYL PYRAZOLE LACTAM ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS
    10.
    发明申请
    SUBSTITUTED BICYCLIC CYCLOALKYL PYRAZOLE LACTAM ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS 审中-公开
    作为MGLUR5受体的独立型调节剂的取代的双环环丙​​基吡唑LACTAM模拟物

    公开(公告)号：US20130345204A1

    公开(公告)日：2013-12-26

    申请号：US13922225

    申请日：2013-06-19

    Applicant: Vanderbilt University

    Inventor： P. Jeffrey Conn ,  Craig W. Lindsley ,  Shaun R. Stauffer ,  José Manuel Bartolomé-Nebreda ,  Susana Conde-Ceide ,  Gregor James Macdonald ,  Han Min Tong

    IPC: C07D487/04

    CPC classification number: C07D487/04

    Abstract: In one aspect, the invention relates to substituted bicyclic cycloalkyl pyrazole lactam analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    Abstract translation: 一方面，本发明涉及可用作代谢型谷氨酸受体亚型5（mGluR5）的正变构调节剂的取代的双环环烷基吡唑内酰胺类似物，其衍生物和相关化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

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