发明申请
US20130345227A1 PYRIDO [2, 3 - B] PYRAZINE DERIVATIVES AND THEIR THERAPEUTICAL USES
有权
吡咯并[2,3-B]吡嗪衍生物及其治疗用途
![PYRIDO [2, 3 - B] PYRAZINE DERIVATIVES AND THEIR THERAPEUTICAL USES](/docs/US/2013-12-26/US20130345227A1/abs.jpg.600x600.jpg)
- 专利标题： PYRIDO [2, 3 - B] PYRAZINE DERIVATIVES AND THEIR THERAPEUTICAL USES
- 专利标题（中）： 吡咯并[2,3-B]吡嗪衍生物及其治疗用途
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申请号： US14002991申请日： 2012-02-13
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公开(公告)号： US20130345227A1公开(公告)日： 2013-12-26
- 发明人: Dieter Dorsch , Alfred Jonczyk , Guenter Hoelzemann , Christiane Amendt , Frank Zenke
- 申请人： Dieter Dorsch , Alfred Jonczyk , Guenter Hoelzemann , Christiane Amendt , Frank Zenke
- 申请人地址： DE Darmstadt
- 专利权人： MERCK PATENT GMBH
- 当前专利权人： MERCK PATENT GMBH
- 当前专利权人地址： DE Darmstadt
- 优先权： EP11001944.5 20110309
- 国际申请： PCT/EP12/00630 WO 20120213
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/4985 ; C07D491/048 ; A61K45/06
![PYRIDO [2, 3 - B] PYRAZINE DERIVATIVES AND THEIR THERAPEUTICAL USES](/abs-image/US/2013/12/26/US20130345227A1/abs.jpg.150x150.jpg)
摘要：
The present invention relates to novel pyrido[2,3-b]pyrazine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.
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