发明申请
US20140005177A1 PYRIDINYL- AND PYRAZINYL-METHYLOXY-ARYL DERIVATIVES USEFUL AS INHIBITORS OF SPLEEN TYROSINE KINASE (SYK)
审中-公开
作为缓冲型酪氨酸激酶（SYK）的抑制剂有用的吡啶基 - 和吡嗪并 - 甲基衍生物
- 专利标题： PYRIDINYL- AND PYRAZINYL-METHYLOXY-ARYL DERIVATIVES USEFUL AS INHIBITORS OF SPLEEN TYROSINE KINASE (SYK)
- 专利标题（中）： 作为缓冲型酪氨酸激酶（SYK）的抑制剂有用的吡啶基 - 和吡嗪并 - 甲基衍生物
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申请号： US14004388申请日： 2012-03-08
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公开(公告)号： US20140005177A1公开(公告)日： 2014-01-02
- 发明人: Francis Louis Atkinson , Michael David Barker , John Liddle , David Matthew Wilson
- 申请人： Francis Louis Atkinson , Michael David Barker , John Liddle , David Matthew Wilson
- 申请人地址： GB Brentford, Middlesex
- 专利权人： GLAXO GROUP LIMITED
- 当前专利权人： GLAXO GROUP LIMITED
- 当前专利权人地址： GB Brentford, Middlesex
- 优先权： GB1104153.0 20110311
- 国际申请： PCT/EP2012/053948 WO 20120308
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; A61K31/4725 ; A61K31/55 ; C07D403/12 ; A61K45/06 ; C07D401/14
摘要：
A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory diseases and/or allergic conditions, in cancer therapy, specifically heme malignancies, and autoimmune conditions.
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