-
1.发明申请Phenyl-Pyrazole Derivatives as Non-Steroidal Glucocorticoid Receptor Ligands 审中-公开苯基吡唑衍生物作为非甾体糖皮质激素受体配体公开(公告)号：US20080207725A1
公开(公告)日：2008-08-28
申请号：US11917775
申请日：2006-06-27
Applicant: Michael David Barker , David House , Haydn Terence Jones , Simon John Fawcett MacDonald , Iain McFarlane Mclay
Inventor： Michael David Barker , David House , Haydn Terence Jones , Simon John Fawcett MacDonald , Iain McFarlane Mclay
IPC: A61K31/415 , C07D403/12 , C07D231/38 , A61P29/00 , A61P37/00 , A61P17/00 , A61K9/12 , A61K31/4155
CPC classification number: C07C215/28 , C07B2200/07 , C07C217/16 , C07D231/38 , C07D307/79 , C07D405/12
Abstract: A compound of formula (I): wherein A represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl; and R1 and R2 each independently represent hydrogen, fluorine or chlorine; or a physiologically functional derivative thereof.
Abstract translation: 式（I）的化合物：其中A表示2,3-二氢-1-苯并呋喃-7-基，5-氟-2-甲氧基 - 苯基或5-氟-2-羟基 - 苯基; R 1和R 2各自独立地表示氢，氟或氯; 或其生理功能衍生物。
-
公开(公告)号：US06426337B1
公开(公告)日：2002-07-30
申请号：US09331526
申请日：1999-08-20
Applicant: Brian Cox , Suzanne Elaine Keeling , David George Allen , Alison Judith Redgrave , Michael David Barker , Heather Hobbs , Thomas Davis Roper, IV , Joanna Victoria Geden
Inventor： Brian Cox , Suzanne Elaine Keeling , David George Allen , Alison Judith Redgrave , Michael David Barker , Heather Hobbs , Thomas Davis Roper, IV , Joanna Victoria Geden
IPC: A61K3170
CPC classification number: C07D473/00 , C07H19/16 , Y10S514/826 , Y10S514/851 , Y10S514/885 , Y10S514/921 , Y10S514/925
Abstract: There are provided according to the invention novel compounds of formula (I) wherein R1, R2, and R3 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
Abstract translation: 根据本发明提供新的式（I）化合物，其中R 1，R 2和R 3如说明书中所述，其制备方法，含有它们的制剂及其在治疗炎性疾病中的用途。
-
公开(公告)号：US08993560B2
公开(公告)日：2015-03-31
申请号：US13414873
申请日：2012-03-08
Applicant: Francis Louis Atkinson , Michael David Barker , John Liddle , David Matthew Wilson
Inventor： Francis Louis Atkinson , Michael David Barker , John Liddle , David Matthew Wilson
IPC: A61K31/55 , C07D401/12 , C07D403/12 , A61K31/4725 , A61K45/06 , C07D401/14
CPC classification number: C07D403/12 , A61K9/0014 , A61K31/4725 , A61K31/55 , A61K45/06 , C07D401/12 , C07D401/14
Abstract: A compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (SYK) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory diseases and/or allergic conditions, in cancer therapy, specifically heme malignancies, and autoimmune conditions.
Abstract translation: 式（I）的化合物或其盐; 其是脾脏酪氨酸激酶（SYK）的抑制剂，因此潜在地用于治疗由肥大细胞，巨噬细胞和B细胞的不适当活化引起的疾病以及相关的炎症反应和组织损伤，例如炎症性疾病和/或过敏性疾病 ，在癌症治疗中，特别是血红素恶性肿瘤和自身免疫病症。
-
公开(公告)号：US07985740B2
公开(公告)日：2011-07-26
申请号：US11995921
申请日：2006-07-17
Applicant: David George Allen , Michael David Barker , Richard Peter Charles Cousins
CPC classification number: C07H19/16
Abstract: The invention provides novel compounds which are agonists of the adenosine 2A receptor along with pharmaceutical compositions thereof, and methods of administering such compounds.
Abstract translation: 本发明提供了作为腺苷2A受体的激动剂及其药物组合物的新化合物，以及施用这些化合物的方法。
-
公开(公告)号：US20090312325A1
公开(公告)日：2009-12-17
申请号：US12474324
申请日：2009-05-29
Applicant: Ian Robert Baldwin , Michael David Barker , Anthony William Dean , Colin David Eldred , Brian Evans , Sharon Lisa Gough , Stephen Barry Guntrip , Julie Nicole Hamblin , Stuart Holman , Paul Jones , Mika Kristian Lindvall , Christopher James Lunniss , Tracy Jane Redfern , Alison Judith Redgrave , John Edward Robinson , Michael Woodrow
Inventor： Ian Robert Baldwin , Michael David Barker , Anthony William Dean , Colin David Eldred , Brian Evans , Sharon Lisa Gough , Stephen Barry Guntrip , Julie Nicole Hamblin , Stuart Holman , Paul Jones , Mika Kristian Lindvall , Christopher James Lunniss , Tracy Jane Redfern , Alison Judith Redgrave , John Edward Robinson , Michael Woodrow
IPC: A61K31/4709 , C07D401/12 , C07D417/12 , C07D403/12 , C07D215/38 , A61K31/47 , A61K31/5377 , A61P29/00 , A61P37/08
CPC classification number: C07D401/12 , C07D215/54 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
Abstract: There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20, and R34 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
Abstract translation: 根据本发明提供新的式（I）化合物或其药学上可接受的盐，其中R1，R2，R19，R20和R34如说明书中所述，其制备方法，含有它们的制剂及其在 治疗炎症性疾病。
-
Patent Agency Ranking
公开(公告)号：US07572915B2
公开(公告)日：2009-08-11
申请号：US11349677
申请日：2006-02-08
Applicant: Michael David Barker , Anthony William Dean , Brian Evans , Stuart Holman , Michael Woodrow
Inventor： Michael David Barker , Anthony William Dean , Brian Evans , Stuart Holman , Michael Woodrow
IPC: C07D215/38
CPC classification number: C07D401/12 , C07D215/54 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
Abstract: There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20, and R34 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
-
公开(公告)号：US20080176891A1
公开(公告)日：2008-07-24
申请号：US11858144
申请日：2007-09-20
Applicant: Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
Inventor： Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
IPC: A61K31/437 , C07D221/04 , A61P29/00 , A61P19/02 , A61P11/06
CPC classification number: C07D471/04
Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to formula (I): and salts thereof.The compounds of the invention are inhibitors of kinase activity, in particular IKK2 activity.
Abstract translation: 本发明涉及某些新化合物。 具体地，本发明涉及根据式（I）的化合物及其盐。 本发明的化合物是激酶活性的抑制剂，特别是IKK2活性。
-
公开(公告)号：US06528494B2
公开(公告)日：2003-03-04
申请号：US10025678
申请日：2001-12-19
Applicant: Brian Cox , Suzanne Elaine Keeling , David George Allen , Alison Judith Redgrave , Michael David Barker , Heather Hobbs , Thomas Davis Roper, IV , Joanna Victoria Geden
Inventor： Brian Cox , Suzanne Elaine Keeling , David George Allen , Alison Judith Redgrave , Michael David Barker , Heather Hobbs , Thomas Davis Roper, IV , Joanna Victoria Geden
IPC: A01N4304
CPC classification number: C07D473/00 , C07H19/16 , Y10S514/826 , Y10S514/851 , Y10S514/885 , Y10S514/921 , Y10S514/925
Abstract: There are provided according to the invention novel compounds of formula I wherein R1, R2 and R3 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
Abstract translation: 根据本发明提供新的式I化合物，其中R 1，R 2和R 3如说明书中所述，其制备方法，含有它们的制剂及其在治疗炎性疾病中的应用。
-
9.发明授权7-(1H-pyrazol-4-yl)-1,6-naphthyridine compounds as Syk inhibitors 失效7-（1H-吡唑-4-基）-1,6-萘啶化合物作为Syk抑制剂公开(公告)号：US08633319B2
公开(公告)日：2014-01-21
申请号：US13642338
申请日：2011-04-27
Applicant: Francis Louis Atkinson , Michael David Barker , Clement Douault , Neil Stuart Garton , John Liddle , Vipulkumar Kantibhai Patel , Alexander George Steven Preston , David Matthew Wilson
Inventor： Francis Louis Atkinson , Michael David Barker , Clement Douault , Neil Stuart Garton , John Liddle , Vipulkumar Kantibhai Patel , Alexander George Steven Preston , David Matthew Wilson
IPC: C07D471/04 , A61K31/4375
CPC classification number: C07D471/04
Abstract: The present invention relates to a compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (Syk) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast and/or basophil cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory disease and/or allergic disorders, and in cancer therapy, specifically heme malignancies, chronic spontaneous urticaria and autoimmune conditions.
Abstract translation: 本发明涉及式（I）化合物或其盐; 其是脾脏酪氨酸激酶（Syk）的抑制剂，因此潜在地用于治疗由桅杆和/或嗜碱性粒细胞，巨噬细胞和B细胞的不适当活化引起的疾病以及相关的炎症反应和组织损伤，例如炎性疾病和 /或过敏性疾病，以及癌症治疗，特别是血红素恶性肿瘤，慢性自发性荨麻疹和自身免疫性疾病。
-
![PYRROLO[2,3-B]PYRIDIN-4-YL-BENZENESULFONAMIDE COMPOUNDS AS 1KK2 INHIBITORS](/abs-image/US/2010/02/11/US20100035917A1/abs.jpg.150x150.jpg)
10.发明申请PYRROLO[2,3-B]PYRIDIN-4-YL-BENZENESULFONAMIDE COMPOUNDS AS 1KK2 INHIBITORS 审中-公开作为1KK2抑制剂的吡咯并[2,3-B]吡啶-4-基 - 苯甲酰胺化合物公开(公告)号：US20100035917A1
公开(公告)日：2010-02-11
申请号：US12442012
申请日：2007-09-20
Applicant: Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
Inventor： Paul Bamborough , Michael David Barker , Sebastien Andre Campos , Richard Peter Charles Cousins , Paul Faulder , Heather Hobbs , Duncan Stuart Holmes , Michael John Johnston , John Liddle , Jeremy John Payne , John Martin Pritchard , Caroline Whitworth
IPC: A61K31/437 , C07D471/04
CPC classification number: C07D471/04
Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds according to Formula (1) and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular 1KK2 activity.
Abstract translation: 本发明涉及某些新化合物。 具体地，本发明涉及根据式（1）的化合物及其盐。 本发明的化合物是激酶活性的抑制剂，特别是1KK2的活性。
-
-
-
-
-
-
-
-
-
Search Results
19
records
(took 0.04 seconds)
