- 专利标题： PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
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申请号： US14025688申请日： 2013-09-12
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公开(公告)号： US20140011796A1公开(公告)日： 2014-01-09
- 发明人: Michael David BARTBERGER , Ana Gonzalez Buenrostro , Hilary Plake Beck , Xiaoqi Chen , Richard Victor Connors , Jeffrey Deignan , Jason Duquette , John Eksterwicz , Benjamin Fisher , Brian Matthew Fox , Jiasheng Fu , Zice Fu , Felix Gonzalez Lopez De Turiso , Michael William Gribble , Dann James Gustin , Julie Anne Heath , Xin Huang , Xianyun Jiao , Michael Johnson , Frank Kayser , David John Kopecky , Sujen Lai , Yihong Li , Zhihong Li , Jiwen Liu , Jonathan Dante Low , Brian Stuart Lucas , Zhihua Ma , Lawrence R. McGee , Joel McIntosh , Dustin McMinn , Julio Cesar Medina , Jeffrey Thomas Mihalic , Steven Howard Olson , Yosup Rew , Philip Marley Roveto , Daqing Sun , Xiaodong Wang , Yingcai Wang , Xuelei Yan , Ming Yu , Jiang Zhu
- 申请人： AMGEN INC.
- 申请人地址： US CA Thousand Oaks
- 专利权人： AMGEN INC.
- 当前专利权人： AMGEN INC.
- 当前专利权人地址： US CA Thousand Oaks
- 主分类号： C07D211/76
- IPC分类号： C07D211/76 ; C07D417/12 ; C07D413/06 ; C07D471/10 ; C07D409/04 ; C07D401/04 ; C07D279/02 ; C07D491/08 ; C07D498/08 ; C07D417/14 ; C07D491/153 ; C07D417/06 ; C07D401/06 ; C07D405/04
摘要：
The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
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