发明申请
US20140024695A1 METHODS OF TREATING ARTHRITIC CONDITIONS USING (+)-2-[1-(3-ETHOXY-4-METHOXYPHENYL)-2-METHYLSULFONYLETHYL]-4-ACETYLAMINOISOINDOLINE 1,3-DIONE
有权
使用(+) - 2- [1-(3-乙氧基-4-甲氧基苯基)-2-甲基磺酰基] -4-乙酰氨基吲哚-1,3-二酮处理芳香族条件的方法
- 专利标题: METHODS OF TREATING ARTHRITIC CONDITIONS USING (+)-2-[1-(3-ETHOXY-4-METHOXYPHENYL)-2-METHYLSULFONYLETHYL]-4-ACETYLAMINOISOINDOLINE 1,3-DIONE
- 专利标题(中): 使用(+) - 2- [1-(3-乙氧基-4-甲氧基苯基)-2-甲基磺酰基] -4-乙酰氨基吲哚-1,3-二酮处理芳香族条件的方法
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申请号: US13682652申请日: 2012-11-20
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公开(公告)号: US20140024695A1公开(公告)日: 2014-01-23
- 发明人: George W. MULLER , Peter H. SCHAFER , Hon-Wah MAN , Chuansheng GE
- 申请人: CELGENE CORPORATION
- 申请人地址: US NJ Summit
- 专利权人: CELGENE CORPORATION
- 当前专利权人: CELGENE CORPORATION
- 当前专利权人地址: US NJ Summit
- 主分类号: A61K31/4035
- IPC分类号: A61K31/4035
摘要:
Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, substantially free of its (−) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discussed. Also discussed are methods of using and pharmaceutical compositions comprising the (+) enantiomer of 2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-α or the inhibition of PDE4.
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