发明申请
US20140030274A1 AMYLOIDOSIS TARGET USEFUL IN METHODS OF TREATMENT AND FOR SCREENING OF COMPOUNDS
有权
用于治疗和筛选化合物的方法中的AMYLIDOSIS目标
- 专利标题： AMYLOIDOSIS TARGET USEFUL IN METHODS OF TREATMENT AND FOR SCREENING OF COMPOUNDS
- 专利标题（中）： 用于治疗和筛选化合物的方法中的AMYLIDOSIS目标
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申请号： US14009360申请日： 2012-03-30
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公开(公告)号： US20140030274A1公开(公告)日： 2014-01-30
- 发明人: Jan Johansson , Jenny Presto
- 申请人： Jan Johansson , Jenny Presto
- 申请人地址： SE Djursholm
- 专利权人： AlphaBeta AB
- 当前专利权人： AlphaBeta AB
- 当前专利权人地址： SE Djursholm
- 优先权： SE1150299-4 20110405
- 国际申请： PCT/SE12/50352 WO 20120330
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; G01N33/50
摘要：
A method involves screening a candidate compound for activity in the treatment of a condition associated with formation of amyloid protein fibrils in a mammal, such as Alzheimer's disease. It is determined whether the trimer/monomer ratio of a chaperone protein is decreased in the presence of the candidate compound. The chaperone protein is or has a high identity to the Brichos domains of Bri2, Bri3 or proSP-C from human. Monomers of the chaperone proteins and/or compounds that promote formation of these monomers are useful for medical treatment of the condition.
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