发明申请
US20140031342A1 6,7-DIHYDROIMIDAZO [2,1-b] [1,3]OXAZINE BACTERICIDES
有权
6,7-二氢吲哚并[2,1-b] [1,3]氧化物杀菌剂
![6,7-DIHYDROIMIDAZO [2,1-b] [1,3]OXAZINE BACTERICIDES](/docs/US/2014-01-30/US20140031342A1/abs.jpg.600x600.jpg)
- 专利标题： 6,7-DIHYDROIMIDAZO [2,1-b] [1,3]OXAZINE BACTERICIDES
- 专利标题（中）： 6,7-二氢吲哚并[2,1-b] [1,3]氧化物杀菌剂
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申请号： US14111262申请日： 2012-04-13
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公开(公告)号： US20140031342A1公开(公告)日： 2014-01-30
- 发明人: Yoshikazu Kawano , Yoshikazu Haraguchi , Hirofumi Sasaki , Yukitaka Uematsu , Hidetsugu Tsubouchi , Hiromi Yata , Hiroshi Shimizu , Kazuho Kohashi , Motohiro Itotani , Kuninori Tai , Isao Takemura , Mikayo Hayashi , Hiroyuki Hashizume , Miki Matsuba , Izuru Nakamura , Xiuhao Chen , Makoto Matsumoto
- 申请人： Yoshikazu Kawano , Yoshikazu Haraguchi , Hirofumi Sasaki , Yukitaka Uematsu , Hidetsugu Tsubouchi , Hiromi Yata , Hiroshi Shimizu , Kazuho Kohashi , Motohiro Itotani , Kuninori Tai , Isao Takemura , Mikayo Hayashi , Hiroyuki Hashizume , Miki Matsuba , Izuru Nakamura , Xiuhao Chen , Makoto Matsumoto
- 申请人地址： JP Chiyoda-ku, Tokyo
- 专利权人： Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人： Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人地址： JP Chiyoda-ku, Tokyo
- 国际申请： PCT/JP2012/060645 WO 20120413
- 主分类号： C07D498/04
- IPC分类号： C07D498/04
![6,7-DIHYDROIMIDAZO [2,1-b] [1,3]OXAZINE BACTERICIDES](/abs-image/US/2014/01/30/US20140031342A1/abs.jpg.150x150.jpg)
摘要：
The present invention provides a novel 6,7-dihydroimidazo[2,1-b][1,3]oxazine compound that has excellent bactericidal action against tubercle bacilli, multidrug-resistant tubercle bacilli, and atypical acid-fast bacilli. Specifically, the present invention provides a compound represented by Formula (1): or a salt thereof, wherein R1 represents tetrahydroisoquinolyl, tetrahydroquinolyl, tetrahydrobenzoazepinyl, benzoxazolyl, benzothiazolyl, indolyl, isoindolinyl, naphthyl, quinolyl, phenyl, biphenylyl, or pyridyl, these groups being optionally substituted, the phenyl, biphenylyl, and pyridyl represented by R1 each being substituted directly or via a linker with at least one group selected from the group consisting of tetrahydropyridyl, diazepanyl, diazabicycloheptanyl, tetrahydrotriazolopyrazinyl, tetrahydroimidazopyrazinyl, azabicyclooctanyl, oxazolyl, piperazinyl, piperidyl, thiazolyl, and the like, each of these groups being optionally substituted; and R2 represents hydrogen or lower alkyl. The present invention further provides a pharmaceutical composition containing the above.
公开/授权文献
- US09051333B2 6,7-dihydroimidazo [2,1-b] [1,3]oxazine bactericides 公开/授权日：2015-06-09
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