Cargo presence detection devices, systems, and methods are described herein. One cargo presence detection system includes one or more sensors positioned in an interior space of a container, and arranged to collect background image data about at least a portion of the interior space of the container and updated image data about the portion of the interior space of the container and a detection component that receives the image data from the one or more sensors and identifies if one or more cargo items are present in the interior space of the container based on analysis of the background and updated image data.