发明申请
US20140051678A1 INHIBITORS OF THE ACTIVITY OF COMPLEX III OF THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN AND USE THEREOF FOR TREATING DISEASES
审中-公开
麻醉药物电子传输链复合物III活性的抑制剂及其用于治疗疾病的用途
- 专利标题： INHIBITORS OF THE ACTIVITY OF COMPLEX III OF THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN AND USE THEREOF FOR TREATING DISEASES
- 专利标题（中）： 麻醉药物电子传输链复合物III活性的抑制剂及其用于治疗疾病的用途
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申请号： US13989319申请日： 2011-11-24
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公开(公告)号： US20140051678A1公开(公告)日： 2014-02-20
- 发明人: Virginie Clement-Schatlo , Thomas Fessard , Riccardo Cribiu
- 申请人： Virginie Clement-Schatlo , Thomas Fessard , Riccardo Cribiu
- 申请人地址： CH Geneva
- 专利权人： STEMERGIE BIOTECHNOLOGY SA
- 当前专利权人： STEMERGIE BIOTECHNOLOGY SA
- 当前专利权人地址： CH Geneva
- 优先权： CH01965/10 20101124
- 国际申请： PCT/IB11/55287 WO 20111124
- 主分类号： C07D491/107
- IPC分类号： C07D491/107 ; A61K31/365 ; A61K31/397 ; A61K31/167 ; C07D267/00 ; C07D321/00 ; C07C235/62
摘要：
The present invention relates to compounds which are inhibitors of the activity of Complex III of the mitochondrial electron transport chain and pharmaceutical compositions comprising said compounds alone or in combination with other active agents. The present invention further relates to use of the compounds of the invention as medicaments or as agrochemicals where their properties as inhibitors of the mitochondrial respiration is of benefit. More particularly the present invention relates to the use of the compounds of the invention in a method of treating and/or preventing cancers presenting tumor-initiating cells. (Formula I) (I)
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