发明申请
- 专利标题： SUBSTITUTED 4-PYRIDONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY
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申请号： US13971369申请日： 2013-08-20
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公开(公告)号： US20140057916A1公开(公告)日： 2014-02-27
- 发明人: Thorsten OOST , Dennnis FIEGEN , Christian GNAMM , Sandra HANDSCHUH , Stefan PETERS , Gerald Juergen ROTH
- 申请人： Thorsten OOST , Dennnis FIEGEN , Christian GNAMM , Sandra HANDSCHUH , Stefan PETERS , Gerald Juergen ROTH
- 申请人地址： DE Ingelheim am Rhein
- 专利权人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH
- 当前专利权人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH
- 当前专利权人地址： DE Ingelheim am Rhein
- 优先权： EP12181539.3 20120823
- 主分类号： C07D213/80
- IPC分类号： C07D213/80 ; C07D401/12 ; C07D413/12 ; C07D493/08 ; C07D409/12 ; C07D405/14 ; C07D401/14 ; C07D213/82 ; C07D405/12
摘要：
This invention relates to substituted 4-pyridones of formula 1and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other auto-immune and allergic disorders, allograft rejection, and oncological diseases.
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