One aspect provides a method comprising: ascertaining an interrupt at an information handling device having two or more cores of different size; determining if the interrupt should be directed to one of a bigger core and a littler core based on a policy for scheduling interrupts; directing the interrupt to the little core if the interrupt does not qualify as an exception based on the policy for scheduling interrupts; and processing the interrupt on an appropriate core according the policy for scheduling interrupts. Other aspects are described and claimed.