Invention Application
- Patent Title: TARGETING COMPLEMENT FACTOR H FOR TREATMENT OF DISEASES
- Patent Title (中): 用于治疗疾病的靶向补充因子H
-
Application No.: US14043317Application Date: 2013-10-01
-
Publication No.: US20140073572A1Publication Date: 2014-03-13
- Inventor: Gary GILKESON , Stephen Tomlinson , V. Michael Holers , Baerbel Rohrer
- Applicant: MUSC Foundation for Research Development , The Regents of the University of Colorado, a Body Corporate
- Applicant Address: US SC Charleston US CO Denver
- Assignee: MUSC Foundation for Research Development,The Regents of the University of Colorado, a Body Corporate
- Current Assignee: MUSC Foundation for Research Development,The Regents of the University of Colorado, a Body Corporate
- Current Assignee Address: US SC Charleston US CO Denver
- Main IPC: C07K14/705
- IPC: C07K14/705 ; C07K14/47
Abstract:
The invention provides a CR2-FH molecule comprising a CR2 portion comprising CR2 protein or a fragment thereof and a FH portion comprising a factor H protein or a fragment thereof, and pharmaceutical compositions comprising a CR2-FH molecule. Also provided are methods of using the compositions for treatment diseases in which the alternative complement pathway is implicated, such as age-related macular degeneration, rheumatoid arthritis, and ischemia reperfusion.
Public/Granted literature
- US09212212B2 Targeting complement factor H for treatment of diseases Public/Granted day:2015-12-15
Information query
