-
公开(公告)号：US20250090734A1
公开(公告)日：2025-03-20
申请号：US18807379
申请日：2024-08-16
Applicant: MUSC Foundation for Research Development
Inventor： David Clyde Fisher, JR. , David Christopher Fitzgerald
IPC: A61M1/14 , A61M1/16 , A61M1/36 , B01D35/147
Abstract: Aspects of the present invention relate to a blood perfusion reservoir device including a housing forming proximal and distal chambers, the housing having proximal and distal openings, a valve having a proximal end, a distal end and a length forming a lumen therebetween, the valve being positioned within the housing such that the proximal end passes through the proximal opening of the housing, the distal end passes through the distal opening of the housing, and the length passes through the proximal and distal chambers of the housing, wherein the valve is configurable between a first and second position, the first position forming a first flow path and the second position forming a second flow path, a filter reservoir having a frame with a filter media forming proximal and distal filter regions with a proximal opening, and positioned within the housing fixedly attached to the valve and surrounding a length of the valve, wherein the first flow path fluidly connects the proximal and distal openings, and the flow bypasses the proximal and distal chambers, the proximal and distal filter regions, and the second flow path fluidly connects the proximal and distal openings, and the flow passes through proximal and distal chambers and the proximal and distal filter regions.
-
公开(公告)号：US20240268968A1
公开(公告)日：2024-08-15
申请号：US18581570
申请日：2024-02-20
Applicant: MUSC Foundation for Research Development
Inventor： Stephen Kalhorn , Mark E. Semler , Joseph Ruscito , Christopher Hapstack
CPC classification number: A61F2/4455 , A61F2/4611 , A61F2002/30471 , A61F2002/3055 , A61F2002/30556 , A61F2002/30884 , A61F2002/30891 , A61F2002/4415 , A61F2002/4445 , A61F2002/4698
Abstract: The present invention provides expandable devices and insertion tools for deploying the expandable devices. The expandable devices are capable of increasing in height and width when expanded from a closed configuration to an open configuration to occupy a larger volume and to present a larger surface area. The expandable devices are lockable and are capable of rigidly occupying a space after expansion. In some embodiments, the expandable devices are useful as interbody devices for spinal fusions.
-
公开(公告)号：US11963980B2
公开(公告)日：2024-04-23
申请号：US16095828
申请日：2017-04-25
Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
Inventor： Chrystal M. Paulos , Michelle H. Nelson , Stefanie R. Bailey
CPC classification number: A61K35/17 , A61K38/19 , A61K39/0011 , A61K39/001156 , A61K39/001168 , A61P35/00 , C12N5/0636 , C12N5/163 , A61K2039/5156 , A61K2039/5158 , C12N2510/00 , G01N2800/52
Abstract: Provided herein are methods for the production of activated CD26high T cells by co-stimulation with inducible coactivator (ICOS). Further provided are methods for treatment of cancer by administration of the of activated CD26high T cells as an adoptive T cell therapy.
-
公开(公告)号：US20240085427A1
公开(公告)日：2024-03-14
申请号：US18259640
申请日：2022-01-04
Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
Inventor： Nathan G. DOLLOFF , Reeder M. ROBINSON
IPC: G01N33/574 , C07K16/28
CPC classification number: G01N33/57488 , C07K16/283 , A61K2039/505 , C07K2317/31 , C07K2317/622 , C07K2317/94 , G01N2333/99
Abstract: The present disclosure is directed to antibodies binding to AGR2 and cancer cells that express or overexpress AGR2, and methods for use thereof.
-
公开(公告)号：US20230399387A1
公开(公告)日：2023-12-14
申请号：US18033464
申请日：2021-11-05
Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Inventor： Federica DEL MONTE , Rakez KAYED
CPC classification number: C07K16/18 , G01N33/6896 , A61P9/00 , C07K2317/31 , G01N2800/32
Abstract: The present disclosure is directed to method of diagnosing and treating heart disease using antibodies that bind to Cofilin, Aβ and/or Tau.
-
Patent Agency Ranking
公开(公告)号：US20230389853A1
公开(公告)日：2023-12-07
申请号：US18449091
申请日：2023-08-14
Applicant: MUSC Foundation for Research Development
Inventor： Nancey Trevanian Tsai , Mark E. Semler
CPC classification number: A61B5/4076 , A61B5/163 , G16H40/67 , G16H50/20 , G16H20/70 , A61B5/0077 , A61B5/1104 , A61B5/162 , A61B5/743 , A61B5/7475
Abstract: A device for measuring eyelid movement in a human subject comprises a housing, at least one stimulator mounted to the housing, and a camera. The at least one stimulator is configured to provide stimulus to one or both eyes of the subject. The camera is configured to collect information related to movement of one or both eyes of the subject. The device also includes a user interface that is configured to control the at least one stimulator and display information collected by the camera.
-
公开(公告)号：US11690549B2
公开(公告)日：2023-07-04
申请号：US17158620
申请日：2021-01-26
Applicant: MUSC Foundation for Research Development
Inventor： Jonathan Edwards , Jessica Barley , Mark Semler
CPC classification number: A61B5/24 , A61B5/0022 , A61B5/296 , A61B5/688 , A61B5/6849 , A61B5/7203 , A61B2505/05
Abstract: A needle electrode fixation device is configured to secure a transdermal needle electrode to a patient. The device includes a base having a body that defines a first portion and a second portion. The first and second portions are rotatable relative to each other. The first portion defines a channel configured to fit a portion of the transdermal needle electrode. The second portion defines a recess configured to fit a tip of the needle electrode. The device further includes an adhesive layer configured to affix the base to the patient.
-
公开(公告)号：US20230191109A1
公开(公告)日：2023-06-22
申请号：US18059503
申请日：2022-11-29
Applicant: MUSC Foundation for Research Development
Inventor： Bashar Badran , Mark George , Doe Jenkins , Daniel Cook
CPC classification number: A61N1/0452 , A61N1/0456 , A61N1/36031 , A61N1/36034 , A61N1/36036
Abstract: The present invention relates to systems for providing noninvasive cranial nerve stimulation and methods for using the same. The present invention administers therapy through electrodes that are noninvasively attached to one or more of a subject’s cranial nerve. The systems can be used to enhancing rehabilitation and recovery by improving neuroplasticity and coupling muscle training with feedback.
-
公开(公告)号：US20230110411A1
公开(公告)日：2023-04-13
申请号：US17936986
申请日：2022-09-30
Inventor： Eric C. Leuthardt , Peter Brunner , Kara Donovan , Aiko Thompson
Abstract: The present disclosure describes devices and methods for detecting motoneuron excitability in a subject in need. The method includes stimulating a cutaneous distribution of a patient’s vagus nerve within a patient’s ear with a nerve stimulating signal; detecting F-wave occurrence with an evoked electromyography paradigm; and adjusting one or more parameters of the nerve stimulating signal to change the F-wave occurrence.
-
公开(公告)号：US11602436B2
公开(公告)日：2023-03-14
申请号：US16847320
申请日：2020-04-13
Applicant: MUSC Foundation for Research Development
Inventor： Mark Evald Semler , Bruce Frankel , Joseph Ruscito
Abstract: An expandable vertebral body device, system, instrument, and methods of assembly and using the device, system, and instrument are disclosed. The vertebral body device includes a body with a first end and a second end, a first rotating member rotatably coupled to the first end, a second rotating member rotatably coupled to the second end, a first extension member moveably coupled to the first end, and a second extension member moveably coupled to the second end. The expandable cage system comprises a vertebral body device and an insertion instrument. Methods for assembling and using the vertebral body device and instrument are also disclosed.
-
-
-
-
-
-
-
-
-
Search Results
294
records
(took 0.027 seconds)
