Invention Application
- Patent Title: Optimized Antibodies That Target CD19
- Patent Title (中): 靶向CD19的优化抗体
-
Application No.: US13959587Application Date: 2013-08-05
-
Publication No.: US20140086906A1Publication Date: 2014-03-27
- Inventor: Matthew J. Bernett , Seung Yup Chu , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Erik Weiking Pong , John O. Richards , Eugene Alexander Zhukovsky
- Applicant: Xencor, Inc.
- Applicant Address: US CA Monrovia
- Assignee: Xencor, Inc.
- Current Assignee: Xencor, Inc.
- Current Assignee Address: US CA Monrovia
- Main IPC: C07K16/28
- IPC: C07K16/28
Abstract:
The present invention describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcgγR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.
Public/Granted literature
- US09803020B2 Optimized antibodies that target CD19 Public/Granted day:2017-10-31
Information query
