公开(公告)号：US20250011440A1

公开(公告)日：2025-01-09

申请号：US18885442

申请日：2024-09-13

Applicant: Xencor, Inc.

Inventor： Aaron Keith Chamberlain ,  Bassil Dahiyat ,  John Desjarlais ,  Sher Bahadur Karki ,  Gregory Lazar

IPC: C07K16/28 ,  A61K39/00 ,  C07K16/08 ,  C07K16/22 ,  C07K16/32

Abstract: The present application relates to optimized IgG immunoglobulin variants, engineering methods for their generation, and their application, particularly for therapeutic purposes.

公开(公告)号：US20240239879A1

公开(公告)日：2024-07-18

申请号：US18440895

申请日：2024-02-13

Applicant: Xencor, Inc.

Inventor： Aaron Keith Chamberlain ,  Bassil Dahiyat ,  John R. Desjarlais ,  Sher Bahadur Karki ,  Gregory Alan Lazar

IPC: C07K16/18 ,  A61K39/00 ,  C07K14/715 ,  C07K16/08 ,  C07K16/22 ,  C07K16/24 ,  C07K16/28 ,  C07K16/32 ,  C07K16/42

CPC classification number: C07K16/18 ,  C07K14/7151 ,  C07K16/082 ,  C07K16/22 ,  C07K16/241 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/2893 ,  C07K16/2896 ,  C07K16/32 ,  C07K16/4291 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/90 ,  C07K2319/30 ,  Y02A50/30

Abstract: The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.

公开(公告)号：US11932685B2

公开(公告)日：2024-03-19

申请号：US17079299

申请日：2020-10-23

Applicant: Xencor, Inc.

Inventor： Aaron Keith Chamberlain ,  Bassil Dahiyat ,  John R. Desjarlais ,  Sher Bahadur Karki ,  Gregory Alan Lazar

IPC: C07K16/00 ,  A61K39/395 ,  C07H21/04 ,  C07K14/715 ,  C07K16/08 ,  C07K16/18 ,  C07K16/22 ,  C07K16/24 ,  C07K16/28 ,  C07K16/32 ,  C07K16/42 ,  C12N1/20 ,  C12N5/00 ,  C12N5/16 ,  C12N15/00 ,  A61K39/00

CPC classification number: C07K16/18 ,  C07K14/7151 ,  C07K16/082 ,  C07K16/22 ,  C07K16/241 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/2893 ,  C07K16/2896 ,  C07K16/32 ,  C07K16/4291 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/90 ,  C07K2319/30 ,  Y02A50/30

Abstract: The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.

公开(公告)号：US11932675B2

公开(公告)日：2024-03-19

申请号：US17067508

申请日：2020-10-09

Applicant: Genentech, Inc. ,  Xencor, Inc.

Inventor： John Desjarlais ,  Matthew Bernett ,  Michael Hedvat ,  Rajat Varma ,  Suzanne Schubbert ,  Christine Bonzon ,  Rumana Rashid ,  Juan Diaz ,  Patrick Holder ,  Christine Huang

IPC: C07K14/00 ,  A61P35/00 ,  C07K14/54 ,  C07K16/28 ,  A61K38/00

CPC classification number: C07K14/5443 ,  A61P35/00 ,  C07K16/2818 ,  A61K38/00 ,  C07K2319/30

Abstract: The present invention relates to fusion proteins comprising variant IL-15 proteins, fusion proteins comprising variant anti-PD-1 antigen binding domains, and fusion proteins comprising variant IL-15 proteins and variant anti-PD-1 antigen binding domains. The present invention also relates to nucleic acid molecules, expression vectors, host cells and methods for making such fusion proteins and the use of such fusion proteins in the treatment of cancer.

公开(公告)号：US20240026002A1

公开(公告)日：2024-01-25

申请号：US18452395

申请日：2023-08-18

Applicant: Xencor, Inc.

Inventor： Matthew J. Bernett ,  Gregory Moore ,  John Desjarlais ,  Michael Hedvat ,  Christine Bonzon

IPC: C07K16/28 ,  A61P35/00 ,  A61P37/06

CPC classification number: C07K16/2818 ,  A61P35/00 ,  A61P37/06 ,  C07K16/2803 ,  C07K16/2827 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/52 ,  C07K2317/33 ,  C07K2317/31 ,  A61K2039/507

Abstract: The present invention is directed to bispecific, heterodimeric immunomodulatory antibodies.

公开(公告)号：US11851466B2

公开(公告)日：2023-12-26

申请号：US17062458

申请日：2020-10-02

Applicant: Xencor, Inc.

Inventor： Matthew Bernett ,  John R. Desjarlais ,  Rajat Varma ,  Ke Liu ,  Rumana Rashid ,  Nargess Hassanzadeh-Kiabi ,  Michael Hedvat

IPC: C07K16/46 ,  C07K14/54 ,  A61P35/00 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K14/5434 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827 ,  A61K2039/505 ,  C07K2317/622 ,  C07K2319/30

Abstract: The present invention relates to targeted IL-12 heterodimeric Fc fusion proteins, where the fusion proteins bind to human PD-1 or human PD-L1.

公开(公告)号：US20230340144A1

公开(公告)日：2023-10-26

申请号：US18172196

申请日：2023-02-21

Applicant: XENCOR, INC.

Inventor： Matthew J. Bernett ,  Seung Yup Chu ,  John R. Desjarlais ,  Sher Bahadur Karki ,  Gregory Alan Lazar ,  Erik Weiking Pong ,  John O. Richards ,  Eugene Alexander Zhukovsky

IPC: C07K16/28

CPC classification number: C07K16/2896 ,  C07K16/2803 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcγR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.

公开(公告)号：US20230227581A1

公开(公告)日：2023-07-20

申请号：US17817334

申请日：2022-08-03

Applicant: Xencor, Inc.

Inventor： Rumana Rashid ,  Umesh S. Muchhal ,  Gregory Moore ,  Alex Nishtal ,  Seung Chu ,  Sung-Hyung Lee ,  Yoon Kyung Kim

IPC: C07K16/40 ,  C07K16/28 ,  C07K16/46 ,  C12N15/63

CPC classification number: C07K16/40 ,  C07K16/2809 ,  C07K16/468 ,  C12N15/63 ,  C07K2317/565 ,  C07K2317/622

Abstract: The present invention is directed to antibodies, including novel antigen binding domains and heterodimeric antibodies, that bind Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3).

公开(公告)号：US20230227560A1

公开(公告)日：2023-07-20

申请号：US17819218

申请日：2022-08-11

Applicant: Xencor, Inc.

Inventor： Seung Yup Chu ,  John R. Desjarlais ,  Sher Bahadur Karki ,  Gregory Alan Lazar ,  Gregory L. Moore ,  Igor Vostiar

IPC: C07K16/28 ,  C07K16/00

CPC classification number: C07K16/283 ,  C07K16/00 ,  C07K16/2803 ,  C07K16/2851 ,  C07K16/2878 ,  C07K2317/52 ,  C07K2317/24 ,  C07K2317/524 ,  C07K2317/53 ,  C07K2317/71 ,  C07K2317/72 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  A61K2039/505

Abstract: The present invention relates to immunoglobulins that bind FcγRIIb+ cells and coengage the antigen on the cell's surface and an FcγRIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins.

公开(公告)号：US20230220081A1

公开(公告)日：2023-07-13

申请号：US18065462

申请日：2022-12-13

Applicant: Xencor, Inc.

Inventor： Matthew Bernett ,  Rumana Rashid ,  John Desjarlais ,  Rajat Varma ,  Christine Bonzon

IPC: C07K16/28 ,  C07K14/54 ,  C07K14/715 ,  C12N15/63 ,  A61P35/00 ,  A61K39/00 ,  A61K38/00

CPC classification number: C07K16/2818 ,  C07K14/5443 ,  C07K14/7155 ,  C12N15/63 ,  A61P35/00 ,  C07K2317/24 ,  C07K2317/524 ,  A61K2039/505 ,  C07K2317/94 ,  C07K2319/30 ,  C07K2317/73 ,  C07K2317/526 ,  C07K2317/35 ,  C07K2317/92 ,  C07K2317/31 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/74 ,  A61K38/00 ,  C07K2319/32

Abstract: The present invention is directed to novel bispecific heterodimeric Fc fusion proteins comprising an IL-15/IL-15Rα Fc-fusion protein and a PD-1 antibody fragment-Fc fusion protein.