发明申请
- 专利标题: NONINVASIVE DETECTION OF FETAL GENETIC ABNORMALITY
- 专利标题(中): 非遗传性检测基因遗传异常
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申请号: US13641080申请日: 2011-06-29
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公开(公告)号: US20140099642A1公开(公告)日: 2014-04-10
- 发明人: Fuman Jiang , Huifei Chen , Xianghua Chai , Yuying Yuan , Xiuqing Zhang , Fang Chen
- 申请人: Fuman Jiang , Huifei Chen , Xianghua Chai , Yuying Yuan , Xiuqing Zhang , Fang Chen
- 申请人地址: CN Shenzhen, Guangdong
- 专利权人: BGI SHENZHEN CO., LIMITED
- 当前专利权人: BGI SHENZHEN CO., LIMITED
- 当前专利权人地址: CN Shenzhen, Guangdong
- 国际申请: PCT/CN2011/001070 WO 20110629
- 主分类号: G06F19/18
- IPC分类号: G06F19/18
摘要:
The current invention is directed to methods for noninvasive detection of fetal genetic abnormalities by large-scale sequencing of nucleotides from maternal biological sample. Further provided are methods to remove GC bias from the sequencing results according to the difference in GC content of a chromosome. The current invention not only makes the detection much more accurate but also represents a comprehensive method for fetal aneuploidy detection including sex chromosome disorders such as XO, XXX, XXY, and XYY, etc.
公开/授权文献
- US09547748B2 Method for determining fetal chromosomal abnormality 公开/授权日:2017-01-17