A high-voltage metal-dielectric-semiconductor transistor includes a semiconductor substrate; a trench isolation region in the semiconductor substrate surrounding an active area; a gate overlying the active area; a drain doping region of a first conductivity type in the active area; a source doping region of the first conductivity type in a first well of a second conductivity type in the active area; and a source lightly doped region of the first conductivity type between the gate and the source doping region; wherein no isolation is formed between the gate and the drain doping region.