发明申请
US20140112954A1 METHOD FOR PREPARING HBV VACCINE COMPRISING ALUMINUM ADJUVANT
审中-公开
用于制备包含铝补充剂的HBV疫苗的方法
- 专利标题： METHOD FOR PREPARING HBV VACCINE COMPRISING ALUMINUM ADJUVANT
- 专利标题（中）： 用于制备包含铝补充剂的HBV疫苗的方法
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申请号： US14117937申请日： 2012-04-18
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公开(公告)号： US20140112954A1公开(公告)日： 2014-04-24
- 发明人: Guixing Li , Ping Zhang , Haichun Zhang , Xinting Chen , Xiaoyu Li , Juan Zhang , Caixia Su
- 申请人： Guixing Li , Ping Zhang , Haichun Zhang , Xinting Chen , Xiaoyu Li , Juan Zhang , Caixia Su
- 申请人地址： CN Dalian, Liaoning
- 专利权人： DALIAN HISSEN BIO-PHARM CO., LTD.
- 当前专利权人： DALIAN HISSEN BIO-PHARM CO., LTD.
- 当前专利权人地址： CN Dalian, Liaoning
- 优先权： CN201110126060.4 20110516
- 国际申请： PCT/CN2012/074274 WO 20120418
- 主分类号： A61K39/29
- IPC分类号： A61K39/29
摘要：
The present invention discloses a method for preparing HBV Vaccine comprising aluminum adjuvant, which belongs to biological technology field. The method, which is characterized in that aluminum adjuvant Al(OH)3 is produced by an on-line reaction, comprises mixing PBS buffer solution and potassium aluminum sulfate (KAl(SO4)2) solution with hepatitis B surface antigen stock solution, adding sodium hydroxide (NaOH) solution into the mixed solution, so that the adjuvant is continuously produced and hepatitis B surface antigens are continuously coated and absorbed simultaneously. The process is called “in-situ adsorption”.
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