发明申请
US20140113312A1 CLASSIFICATION OF KINASE INHIBITORS USING NONLINEAR OPTICAL TECHNIQUES
有权
使用非线性光学技术对激素抑制剂进行分类
- 专利标题： CLASSIFICATION OF KINASE INHIBITORS USING NONLINEAR OPTICAL TECHNIQUES
- 专利标题（中）： 使用非线性光学技术对激素抑制剂进行分类
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申请号： US14006302申请日： 2012-03-21
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公开(公告)号： US20140113312A1公开(公告)日： 2014-04-24
- 发明人: Joshua S. Salafsky , Ryan McGuinness
- 申请人： Joshua S. Salafsky , Ryan McGuinness
- 申请人地址： US CA Burlingame
- 专利权人： Biodesy, Inc.
- 当前专利权人： Biodesy, Inc.
- 当前专利权人地址： US CA Burlingame
- 国际申请： PCT/US2012/030010 WO 20120321
- 主分类号： C12Q1/48
- IPC分类号： C12Q1/48
摘要：
A method is disclosed for classifying and distinguishing between type I and type II kinase inhibitors. The method involves the use of non-linear optical techniques, in particular second-harmonic generation (SHG) to identify conformational changes in kinase proteins obtained from known type I or type II inhibitors. The method further involves deducing the manner of binding of unknown inhibitors by comparison with the signal changes produced by known ligands. The method is also applied to comparing the conformational changes induced by the binding of generic and branded kinase inhibitor drugs to a target kinase.