A hybrid imaging system including a first imaging system configured to acquire low resolution anatomical data of a first field of view of an anatomical structure. A second imaging system is configured to acquire functional data of the first field of view of the anatomical structure. A reconstruction processor is configured to reconstruct the functional data based on attenuation data into an attenuation corrected image. In response to the attenuation corrected image showing regions of interest, with the first imaging system or another imaging system acquiring high resolution data of one or more portions of the first field of view containing the regions of interest. The reconstruction processor reconstructs the high resolution anatomical data into one or more high resolution images of the regions of interest.