Invention Application
- Patent Title: PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES
- Patent Title (中): 在重复生产聚氨酯时防止结缔组织减少
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Application No.: US14043758Application Date: 2013-10-01
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Publication No.: US20140128575A1Publication Date: 2014-05-08
- Inventor: Yung-Hsiang KAO , Michael W. LAIRD , Melody Trexler SCHMIDT , Rita L. WONG , Daniel P. HEWITT
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Main IPC: C07K16/28
- IPC: C07K16/28
Abstract:
The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.
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