发明申请
- 专利标题： INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM
- 专利标题（中）： 细菌III型分泌系统的抑制剂
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申请号： US14232445申请日： 2012-07-13
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公开(公告)号： US20140142134A1公开(公告)日： 2014-05-22
- 发明人: Donald T. Moir , Daniel Aiello , Norton P. Peet , John D. Williams , Matthew Torhan
- 申请人： Donald T. Moir , Daniel Aiello , Norton P. Peet , John D. Williams , Matthew Torhan
- 申请人地址： US MA Worcester
- 专利权人： MICROBIOTIX, INC.
- 当前专利权人： MICROBIOTIX, INC.
- 当前专利权人地址： US MA Worcester
- 国际申请： PCT/US2012/046676 WO 20120713
- 主分类号： C07D491/056
- IPC分类号： C07D491/056 ; A61K31/36 ; C07D405/12 ; A61K45/06 ; C07C235/34 ; A61K31/165 ; A61K31/4355 ; C07D317/50 ; A61K31/443
摘要：
Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Psendomonas spp., Yersinia spp., en tero pathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.
公开/授权文献
- US09340551B2 Inhibitors of bacterial type III secretion system 公开/授权日：2016-05-17
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