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公开(公告)号:US09340551B2
公开(公告)日:2016-05-17
申请号:US14232445
申请日:2012-07-13
IPC分类号: C07D405/00 , A61K31/44 , C07D491/056 , A61K31/443 , A61K31/381 , A61K31/53 , A61K31/165 , A61K31/36 , A61K31/4355 , A61K45/06 , C07C235/34 , C07D317/50 , C07D405/12
CPC分类号: C07D491/056 , A61K31/165 , A61K31/36 , A61K31/381 , A61K31/4355 , A61K31/443 , A61K31/53 , A61K45/06 , C07C235/34 , C07D317/50 , C07D405/12 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要: Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Psendomonas spp., Yersinia spp., en tero pathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.
摘要翻译: 公开了显示抑制由细菌III型分泌系统介导的效应物毒素分泌或易位的能力的有机化合物。 公开的III型分泌系统抑制剂化合物可用于抵抗革兰氏阴性细菌如沙门氏菌属,志贺氏菌属(Psigomonas spp。),耶尔森菌属(Yersinia spp。),肠道致病性和肠内侵袭性大肠杆菌以及衣原体属(Chlamydia spp)的感染。 具有这种III型分泌系统。
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公开(公告)号:US20120064062A1
公开(公告)日:2012-03-15
申请号:US13231769
申请日:2011-09-13
申请人: Jon D. Goguen , Daniel Aiello , Donald T. Moir , Bing Li
发明人: Jon D. Goguen , Daniel Aiello , Donald T. Moir , Bing Li
IPC分类号: A61K31/357 , C07D333/34 , A61K31/381 , C07C311/21 , A61K31/18 , C07D405/12 , C07D217/18 , A61K31/443 , A61K31/472 , A61P31/04 , A61P31/00 , A61K39/395 , A61P31/12 , A61P35/00 , A61P25/04 , A61P37/04 , A61K38/22 , A61P25/00 , A61P1/08 , A61P37/08 , A61K38/18 , A61P25/20 , A61P21/02 , A61P23/00 , A61P25/08 , A61P25/24 , A61P25/18 , C07D319/16
CPC分类号: C07D319/18 , A61K31/18 , A61K31/357 , A61K31/381 , A61K31/443 , A61K45/06 , C07D217/14 , C07D333/34 , C07D405/12 , A61K2300/00
摘要: Organic compounds showing the ability to inhibit bacterial omptin proteases, specifically Yersinia pestis plasminogen activator (Pla) are disclosed. The disclosed Y. pestis plasminogen activator inhibitor compounds are useful for treating, preventing, or reducing the spread of infections by Y. pestis.
摘要翻译: 公开了表现出抑制细菌卵黄蛋白酶,特别是鼠疫耶尔森氏菌纤溶酶原激活物(Pla)的能力的有机化合物。 所公开的鼠疫球菌纤溶酶原激活物抑制剂化合物可用于治疗,预防或减少鼠疫耶尔森氏菌感染的传播。
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公开(公告)号:US20140219995A1
公开(公告)日:2014-08-07
申请号:US14232520
申请日:2012-07-13
IPC分类号: C07D471/04 , A61K31/36 , C07C235/20 , A61K31/165 , C07D311/58 , A61K31/353 , C07D207/27 , A61K31/4015 , C07D319/08 , C07D235/26 , A61K31/4184 , C07D215/06 , A61K31/47 , C07D217/12 , A61K31/472 , A61K31/437 , A61K45/06 , C07D317/58
CPC分类号: C07D471/04 , A61K31/165 , A61K31/275 , A61K31/343 , A61K31/353 , A61K31/357 , A61K31/36 , A61K31/4015 , A61K31/402 , A61K31/4184 , A61K31/437 , A61K31/47 , A61K31/472 , A61K31/4741 , A61K45/06 , C07C235/20 , C07D207/27 , C07D215/06 , C07D217/12 , C07D235/26 , C07D311/58 , C07D317/58 , C07D319/08 , Y02A50/473 , Y02A50/475 , Y02A50/481 , A61K2300/00
摘要: Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Pseudomonas spp., Yersinia spp., enteropathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.
摘要翻译: 公开了显示抑制由细菌III型分泌系统介导的效应物毒素分泌或易位的能力的有机化合物。 所公开的III型分泌系统抑制剂化合物可用于抵抗革兰氏阴性菌如沙门氏菌属,志贺氏菌属,假单胞菌属,耶尔森氏菌属,肠致病性肠炎和肠毒素性大肠杆菌和衣原体属的感染。 具有这种III型分泌系统。
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公开(公告)号:US08906945B2
公开(公告)日:2014-12-09
申请号:US13263071
申请日:2010-04-06
IPC分类号: A61K31/34 , A61K31/36 , A61K31/38 , A61K31/41 , A61K31/44 , A61K31/415 , A61K31/496 , A61K31/381 , A61K31/5375 , A61K31/4245 , A61K45/06 , A61K31/407 , A61K31/216 , A61K31/427 , A61K31/16 , A61K31/4184 , A61K31/429 , A61K31/167 , A61K31/4152
CPC分类号: A61K31/4245 , A61K31/16 , A61K31/167 , A61K31/216 , A61K31/34 , A61K31/36 , A61K31/381 , A61K31/407 , A61K31/4152 , A61K31/4184 , A61K31/427 , A61K31/429 , A61K31/496 , A61K31/5375 , A61K45/06 , Y02A50/406 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要: Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Pseudomonas spp., Yersinia spp., enteropathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.
摘要翻译: 公开了显示抑制由细菌III型分泌系统介导的效应物毒素分泌或易位的能力的有机化合物。 所公开的III型分泌系统抑制剂化合物可用于抵抗革兰氏阴性菌如沙门氏菌属,志贺氏菌属,假单胞菌属,耶尔森氏菌属,肠致病性肠炎和肠毒素性大肠杆菌和衣原体属的感染。 具有这种III型分泌系统。
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公开(公告)号:US20120114633A1
公开(公告)日:2012-05-10
申请号:US13263071
申请日:2010-04-06
IPC分类号: A61K31/5377 , C07D513/04 , C07D413/12 , C07D265/32 , C07C229/40 , C07C237/20 , C07D211/34 , A61K31/36 , A61K31/429 , A61K31/5375 , A61K31/216 , A61K31/167 , A61K31/4409 , A61K39/40 , A61P31/04 , A61P37/04 , A61K38/18 , C07D317/60
CPC分类号: A61K31/4245 , A61K31/16 , A61K31/167 , A61K31/216 , A61K31/34 , A61K31/36 , A61K31/381 , A61K31/407 , A61K31/4152 , A61K31/4184 , A61K31/427 , A61K31/429 , A61K31/496 , A61K31/5375 , A61K45/06 , Y02A50/406 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要: Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Pseudomonas spp., Yersinia spp., enteropathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.
摘要翻译: 公开了显示抑制由细菌III型分泌系统介导的效应物毒素分泌或易位的能力的有机化合物。 所公开的III型分泌系统抑制剂化合物可用于抵抗革兰氏阴性菌如沙门氏菌属,志贺氏菌属,假单胞菌属,耶尔森氏菌属,肠致病性肠炎和肠毒素性大肠杆菌和衣原体属的感染。 具有这种III型分泌系统。
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公开(公告)号:US20140142134A1
公开(公告)日:2014-05-22
申请号:US14232445
申请日:2012-07-13
IPC分类号: C07D491/056 , A61K31/36 , C07D405/12 , A61K45/06 , C07C235/34 , A61K31/165 , A61K31/4355 , C07D317/50 , A61K31/443
CPC分类号: C07D491/056 , A61K31/165 , A61K31/36 , A61K31/381 , A61K31/4355 , A61K31/443 , A61K31/53 , A61K45/06 , C07C235/34 , C07D317/50 , C07D405/12 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要: Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Psendomonas spp., Yersinia spp., en tero pathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.
摘要翻译: 公开了显示抑制由细菌III型分泌系统介导的效应物毒素分泌或易位的能力的有机化合物。 公开的III型分泌系统抑制剂化合物可用于抵抗革兰氏阴性细菌如沙门氏菌属,志贺氏菌属(Psigomonas spp。),耶尔森菌属(Yersinia spp。),肠道致病性和肠内侵袭性大肠杆菌以及衣原体属(Chlamydia spp)的感染。 具有这种III型分泌系统。
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