发明申请
US20140147470A1 METHODS OF PREDICTING HOST RESPONSIVENESS TO CANCER IMMUNOTHERAPIES BY EX VIVO INDUCTION OF LEUKOCYTE-FUNCTION-ASSOCIATED mRNAs
审中-公开
通过EXVIVO诱导低密度脂蛋白功能相关mRNA的方法预测对癌症免疫应答的反应
- 专利标题： METHODS OF PREDICTING HOST RESPONSIVENESS TO CANCER IMMUNOTHERAPIES BY EX VIVO INDUCTION OF LEUKOCYTE-FUNCTION-ASSOCIATED mRNAs
- 专利标题（中）： 通过EXVIVO诱导低密度脂蛋白功能相关mRNA的方法预测对癌症免疫应答的反应
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申请号： US14233365申请日： 2012-07-18
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公开(公告)号： US20140147470A1公开(公告)日： 2014-05-29
- 发明人: Masato Mitsuhashi , Yoichi Kato
- 申请人： Masato Mitsuhashi , Yoichi Kato
- 申请人地址： JP Tokyo JP Yokohama, Kanagawa US CA Irvine
- 专利权人： HITACHI CHEMICAL C., LTD.,SHIN YOKOHAMA KATO CLINIC,HITACHI CHEMICAL RESEARCH CENTER, INC.
- 当前专利权人： HITACHI CHEMICAL C., LTD.,SHIN YOKOHAMA KATO CLINIC,HITACHI CHEMICAL RESEARCH CENTER, INC.
- 当前专利权人地址： JP Tokyo JP Yokohama, Kanagawa US CA Irvine
- 国际申请： PCT/US2012/047240 WO 20120718
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
Embodiments of the invention relate generally to ex vivo methods of quantifying expression of leukocyte-function associated mRNAs and using the quantification to characterize an individual's potential responsiveness to cancer immunotherapy. Certain embodiments relate to methods to monitor the efficacy of ongoing cancer immunotherapy by evaluating expression of leukocyte-function associated mRNAs genes before and administration of an anti-cancer immunotherapy regimen.