公开(公告)号：US20140147470A1

公开(公告)日：2014-05-29

申请号：US14233365

申请日：2012-07-18

申请人： Masato Mitsuhashi ,  Yoichi Kato

发明人： Masato Mitsuhashi ,  Yoichi Kato

IPC分类号： C12Q1/68

摘要： Embodiments of the invention relate generally to ex vivo methods of quantifying expression of leukocyte-function associated mRNAs and using the quantification to characterize an individual's potential responsiveness to cancer immunotherapy. Certain embodiments relate to methods to monitor the efficacy of ongoing cancer immunotherapy by evaluating expression of leukocyte-function associated mRNAs genes before and administration of an anti-cancer immunotherapy regimen.

摘要翻译： 本发明的实施方案一般涉及量化白细胞功能相关mRNA表达的离体方法，并且使用定量来表征个体对癌症免疫治疗的潜在反应性。 某些实施方案涉及通过评估白细胞功能相关mRNA基因的表达并施用抗癌免疫治疗方案来监测正在进行的癌症免疫治疗的功效的方法。

公开(公告)号：US09150920B2

公开(公告)日：2015-10-06

申请号：US13695755

申请日：2011-05-03

申请人： Masato Mitsuhashi ,  Ernest C. Borden

发明人： Masato Mitsuhashi ,  Ernest C. Borden

IPC分类号： C12Q1/68 ,  C12Q1/70

CPC分类号： C12Q1/6876 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

摘要： Embodiments of the invention relate generally to ex vivo methods of quantifying expression of interferon responsive genes and characterizing an individual's potential responsiveness to interferon administration. Certain embodiments relate to methods to monitor the efficacy of ongoing interferon therapy by evaluating expression of interferon responsive genes before and after interferon administration.

摘要翻译： 本发明的实施方案一般涉及定量干扰素应答基因的表达的离体方法，并表征个体对干扰素施用的潜在反应性。 某些实施方案涉及通过评估干扰素施用前后的干扰素应答基因的表达来监测正在进行的干扰素疗法的功效的方法。

公开(公告)号：US08783810B2

公开(公告)日：2014-07-22

申请号：US13411092

申请日：2012-03-02

申请人： Tomohiro Yuda ,  Masato Mitsuhashi ,  Sumito Anzai

发明人： Tomohiro Yuda ,  Masato Mitsuhashi ,  Sumito Anzai

IPC分类号： B41J29/38 ,  B41J19/14 ,  B41J2/21

CPC分类号： B41J19/142 ,  B41J2/2132

摘要： To improve positioning accuracy in a direction of relative movement of dots which are formed by a fluid ejection device in which a plurality of nozzle groups contained in the direction of the relative movement of the head section contain a plurality of nozzles in the direction of the relative movement, an ejection timing is set for adjusting in a direction of the relative movement the positions of dots formed by each of nozzle groups. A distribution of adjustment pixels is set for adjusting in the direction of the relative movement the positions of dots formed by each of nozzles. A fluid is ejected in accordance with raster data generated on the basis of a distribution of the adjustment pixels set by an adjustment pixel setting unit, on the basis of ejection timing set by a nozzle group timing setting unit.

摘要翻译： 为了提高由流体喷射装置形成的点的相对运动方向上的定位精度，其中包含在头部相对运动方向上的多个喷嘴组在相对方向上包含多个喷嘴 设置喷射时刻，以便在相对运动的方向上调整由每个喷嘴组形成的点的位置。 设置调整像素的分布，以便在相对运动的方向上调整由每个喷嘴形成的点的位置。 根据由调整像素设定单元设定的调整像素的分布而生成的光栅数据，基于由喷嘴群定时设定单元设定的喷射时刻喷射流体。

公开(公告)号：US08708589B2

公开(公告)日：2014-04-29

申请号：US13216994

申请日：2011-08-24

申请人： Masato Mitsuhashi ,  Sumito Anzai

发明人： Masato Mitsuhashi ,  Sumito Anzai

IPC分类号： B41J11/66 ,  B41J11/70

CPC分类号： B65H35/04 ,  B65H29/20 ,  B65H2404/1441 ,  B65H2601/421 ,  Y10T83/04 ,  Y10T83/4592

摘要： The transport control section controls, at the time of cutting of the long sheet by the cutting unit, the motor for pinching such that a downstream portion in the transport direction, which is cut from the sheet, remains pinched by the first roller and the second roller at the point of time of completion of cutting, and controls, after the completion of cutting, the motor for discharge such that the downstream portion is discharged downstream in the transport direction by rotation of the respective rollers which pinch the downstream portion.

摘要翻译： 运输控制部分在通过切割单元切割长片材时控制用于夹持的电动机，使得从片材切割的输送方向上的下游部分保持被第一辊挤压，而第二辊 在完成切割的时间点之后，控制用于排出的电动机，使得下游部分通过夹持下游部分的各个辊的旋转沿输送方向向下游排出。

公开(公告)号：US08268982B2

公开(公告)日：2012-09-18

申请号：US10585393

申请日：2005-01-07

申请人： Masato Mitsuhashi

发明人： Masato Mitsuhashi

IPC分类号： C07H21/04 ,  C12Q1/68 ,  C12P19/34 ,  C12N9/00

CPC分类号： C12Q1/686 ,  C12Q2561/101

摘要： Provided herein are primer/probe sets useful for detecting HIV (HIV-1) in a test sample. The primer/probe sets can be employed according to nucleic acid amplification procedures including PCR, real-time quantitative PCR, or RT-PCR. The primer/probe sets can also be provided in the form of a kit with other reagents for performing a nucleic acid amplification reaction.

摘要翻译： 本文提供了可用于检测测试样品中HIV（HIV-1）的引物/探针组。 可以根据包括PCR，实时定量PCR或RT-PCR的核酸扩增方法使用引物/探针组。 引物/探针组还可以以试剂盒的形式提供用于进行核酸扩增反应的其它试剂。

公开(公告)号：US20120174653A1

公开(公告)日：2012-07-12

申请号：US13386142

申请日：2010-06-11

申请人： Yoshikatsu Ikawa ,  Masato Mitsuhashi ,  Kazunari Ide

发明人： Yoshikatsu Ikawa ,  Masato Mitsuhashi ,  Kazunari Ide

IPC分类号： F01N11/00

CPC分类号： F01N9/002 ,  F01N3/021 ,  F01N2900/1606 ,  F02D41/1456 ,  F02D41/1467 ,  F02D2200/0812 ,  Y02T10/20 ,  Y02T10/47

摘要： Providing a PM emission amount estimation device for the diesel engine wherein the accuracy of the correction in correcting the basic level of the PM emission amount by use of the PM emission amount estimation map can be enhanced; and, the PM emission amount particularly during the transient state of the engine operation condition can be accurately computed so as to estimate, with high precision, the PM emission amount and the PM emission accumulated-amount (integrated amount) during the whole engine operation conditions including the transient state as well as the steady state. A PM emission amount estimation device for estimating the amount of the PM for estimating the amount of the PM that is emitted from a diesel engine and collected by a DPF provided in the exhaust gas passage of the engine, the device including, but not limited to: a PM emission amount estimation base-map 3 with which the base PM emission amount is computed in response to the operation condition of the engine; a PM emission amount estimation correction-map 5 that determines a correction factor for correcting the base PM emission amount computed by the PM emission amount estimation base-map 3, the correction factor being determined in response to the transient engine operation condition; a transient state judgment device 7 that judges that the engine is operated in a transient operation condition based on the change of the air excess ratio regarding the engine; a PM emission amount computation device 9 that corrects the computed base PM emission amount by multiplying the computed base PM emission amount by the correction factor computed with the PM emission amount estimation correction-map 5 only in a case where it is judged, by the transient state judgment device 7, that the engine is in a transient operation condition whereas the base PM emission amount is directly outputted in a case where it is judged that the engine is in a steady operation condition.

公开(公告)号：US20120132103A1

公开(公告)日：2012-05-31

申请号：US13388195

申请日：2010-07-26

申请人： Katsuyuki Tsugita ,  Masato Mitsuhashi

发明人： Katsuyuki Tsugita ,  Masato Mitsuhashi

IPC分类号： C09G1/04 ,  C07C309/14

CPC分类号： C07C309/14 ,  C07C305/04 ,  C09G1/14

摘要： A fluorine-containing compound exhibiting excellent surface tension-reducing ability despite the absence of perfluoroalkyl group having a chain length of 8 or more which had been the cause of the PFOS and PFOA problems and use of a fluorine material with low environmental load is provided. Also provided are a fluorine-containing surfactant and a composition thereof, an aqueous resin emulsion and a floor polish composition containing such surfactant. The fluorine-containing compound is represented by the following formula (1): Rf1—CpH2p—CH(OH)—CqH2q—NR—CrH2r—(O)n—SO3M  (1) wherein Rf1 is a C1-6 perfluoroalkyl group, p, q, and r are independently an integer of 1 to 6, M is a cationic atom or atomic group, n is 0 or 1, R is hydrogen atom, a C1-12 alkyl group, or a group represented by the following formula (2): Rf2—CsH2s—CH(OH)—CtH2t—  (2) wherein Rf2 is a C1-6 perfluoroalkyl group, and s and t are independently an integer of 1 to 6.

摘要翻译： 提供了尽管不具有全氟烷基的链长为8或更大的全氟烷基，其具有优异的表面张力降低能力的含氟化合物，这是PFOS和PFOA问题的原因，以及使用环境负荷低的氟材料。 还提供了含氟表面活性剂及其组合物，水性树脂乳液和含有这种表面活性剂的地板油漆组合物。 含氟化合物由下式（1）表示：Rf1-CpH2p-CH（OH）-CqH2q-NR-CrH2r-（O）n-SO3M（1）其中Rf1为C1-6全氟烷基，p ，q和r分别为1〜6的整数，M为阳离子性原子或原子团，n为0或1，R为氢原子，碳原子数为1〜12的烷基或下述式 2）：Rf2-CsH2s-CH（OH）-CtH2t-（2）其中Rf2为C1-6全氟烷基，s和t独立地为1〜6的整数。

公开(公告)号：US07838239B2

公开(公告)日：2010-11-23

申请号：US12296425

申请日：2007-04-05

申请人： Masato Mitsuhashi ,  Stephan R. Targan

发明人： Masato Mitsuhashi ,  Stephan R. Targan

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158

摘要： A method is disclosed for determining whether a human having Crohn's disease is likely to respond to a therapy targeting a TNFSF member or a cytokine by measuring the level of certain mRNAs in response to a stimulus. A method of evaluating the effectiveness of a Crohn's disease therapy in a human is also disclosed. Furthermore, a method of screening compounds for use in the treatment of Crohn's disease is disclosed. A method of monitoring the disease state over time in Crohn's disease patients is also disclosed.

摘要翻译： 公开了一种用于通过测量响应于刺激的某些mRNA的水平来确定克罗恩病患者是否可能对靶向TNFSF成员或细胞因子的治疗作出反应的方法。 还公开了评估人类克罗恩病治疗有效性的方法。 此外，公开了一种筛选用于治疗克罗恩病的化合物的方法。 还公开了一种在克罗恩病患者中随时间监测疾病状态的方法。

公开(公告)号：US20080206761A1

公开(公告)日：2008-08-28

申请号：US11913058

申请日：2006-04-28

申请人： Masato Mitsuhashi

发明人： Masato Mitsuhashi

IPC分类号： C12Q1/68

CPC分类号： A61K36/07 ,  A61K31/07 ,  A61K31/34 ,  A61K31/355 ,  A61K31/593 ,  A61K36/746 ,  A61K36/8962 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5308

摘要： A method is disclosed for individually tailoring the administration of dietary components such as supplements. In the method, whole blood of a mammal is exposed to a dietary component. The level of a marker mRNA linked to a disease state is measured in leukocytes after exposure to the dietary component, and in some cases after further stimulation of the exposed blood cells. By comparing the mRNA level after exposure with the value found in unexposed blood cells, it is possible to determine what the effect of the dietary component will be in the mammal. By screening blood of the mammal against a number of possible dietary components, it is possible to develop an optimized set of dietary components tailored to the specific mammal to treat or prevent a disease state.

摘要翻译： 公开了一种单独定制膳食成分如补充剂的施用的方法。 在该方法中，哺乳动物的全血暴露于饮食组分。 在暴露于饮食组分之后，在白细胞中测量与疾病状态相关的标记物mRNA的水平，并且在一些情况下在进一步刺激暴露的血细胞后测量。 通过将暴露后的mRNA水平与未暴露的血细胞中发现的值进行比较，可以确定饮食成分在哺乳动物中的作用。 通过筛选哺乳动物对许多可能的饮食组分的血液，可以开发针对特定哺乳动物定制的优化的膳食组分，以治疗或预防疾病状态。

公开(公告)号：US20060199212A1

公开(公告)日：2006-09-07

申请号：US11376018

申请日：2006-03-15

申请人： Masato Mitsuhashi

发明人： Masato Mitsuhashi

IPC分类号： C12Q1/68 ,  C12N1/08

CPC分类号： C12N15/1006 ,  C12N1/066 ,  C12Q1/6806 ,  C12Q1/6846 ,  C12Q2565/537 ,  C12Q2521/107 ,  C12Q2527/137 ,  C12Q2527/125

摘要： Disclosed are a method, device kit, and automated system for simple, reproducible, and high-throughput quantification of mRNA from whole blood. More particularly, the method, device, kit and automated system involve combinations of leukocyte filters attached to oligo(dT)-immobilized multi-well plates.

摘要翻译： 公开了一种用于从全血中简单，可重复和高通量定量mRNA的方法，装置试剂盒和自动化系统。 更具体地，方法，装置，试剂盒和自动化系统涉及附着于寡聚（dT）活化的多孔板的白细胞过滤器的组合。